青年男性勃起功能障碍与代谢综合征相关性研究分析

Study on the correlation between young males with erectile dysfunction and metabolic syndrome

目的:探讨青年男性勃起功能障碍(Erectile dysfunction,ED)与代谢综合征(Metabolic syndrome,MS)之间的关系,寻找影响青年ED患者中MS的主要危险因素。方法:各调查120名青年男性ED患者(ED组)及性生活正常男性(非ED组)的一般情况、体格检查、脂质代谢、空腹血糖及国际勃起功能评分5项(Internationalindex of erectile function 5,IIEF-5),并按照国际糖尿病联盟提出对MS的诊断标准(IDF2005)。其次对ED组进行视听性刺激模式检查(Udio visual sexual stimulation,AVSS),评估ED伴MS组与非MS组阴茎勃起功能各项指标情况。结果:ED组MS患病率为35%,明显高于非ED组MS患病率15%(P<0.01)。ED组较非ED组中心性肥胖指标(腰围、体重、体重指数)及甘油三脂(TG)浓度水平明显升高(P<0.01),高密度脂蛋白(HDL)明显降低(P<0.01),并伴有总胆固醇(TC)、低密度脂蛋白(LDL)上升(P<0.05),而血压及空腹血糖(FPG)差异无统计学意义(P>0.05)。其次,ED组伴有MS较非MS病情严重(P<0.05),并且随MS危险因素增多,IIEF-5评分逐渐降低。ED伴MS组AVSS各项指标均差于非MS组(P<0.05)。结论:青年ED患者MS患病率明显增高,ED严重程度与MS危险因素数量呈正相关性;中心性肥胖和高脂血症可能是构成青年ED的主要危险因素。

Objective：To investigate the relationship between young men with erectile dysfunction and metabolic syndrome and to find the major risk factors affecting young ED patients. Methods： 120 young ED patients and 40 males with normal sexual life were investigated by physical examination, lipid metabolism, fasting plasma glucose and International index of erectile function 5. The clinical diagnostic criteria of metabolic syndrome was according to the 2005 International Diabetes Federation issued by the international academic community. The ED patients with non-MS and MS also examined Audio visual sexual stimulation to assess the erectile function indicators. Resuits：The prevalence rate of MS in ED group was 35% which was significantly higher than 15% in non-ED group （P〈0.01）. The index central obesity （waist circumference, weight, body mass index） and triglyceride（TG） lev els of patients in ED group were significantly higher than the patients in non ED group （P〈0.01）, while high density lipoprotein（HDL） was significantly lower （P〈0.01）, total cholesterol（TC） and low density lipoprotein （LDL） was higher （P〈0.05）, but blood pressure and fasting plasma glucose （FPG） was no significant difference （P〉0.05）. Secondly, compared with the El） group with non-MS, the patients with MS were much severer （P〈 0.05）, and IIEF-5 score reduced with the increase number of the risk factors of MS. Finally, AVSS indicators of ED patients with MS were inferior to the non-MS group （P〈0.05）. Conclusions：The prevalence of MS in young ED patients is significantly high and the severity of ED is positively correlated with the number of MS risk factors, in which central obesity and hyperlipidemia may be the major risk factors.