女性尿道神经鞘瘤2例报告及文献复习

Schwannomas of female urethra:Report of 2 cases and review of literature

目的:探讨女性尿道神经鞘瘤(Schwannomas of female urethra)的临床及病理特点、诊治方法。方法:回顾性分析我院2002年1月～2012年1月收治的2例尿道神经鞘瘤患者的临床资料:2例患者均为女性,年龄42岁和48岁,均误诊为尿道肉阜,行尿道肉阜切除术。并结合文献复习,分析其临床特点。结果:1例术后病理回报为神经鞘瘤,免疫组织化学检查有特异性表现。1例1年后因肿瘤复发再次入院,行尿道肿物切除术,病理回报为低度恶性神经鞘瘤,术后未予进一步治疗,目前患者状况良好。结论:泌尿系神经鞘瘤临床上少见,而发生恶变者更为罕见。其诊断缺乏特异性,常误诊为尿道肉阜,确诊主要依靠病理和免疫组织化学检查;治疗方法可采用尿道肿物切除术。

Objective：Summarize the clinical and pathological features, diagnosis and treatment of schwanno- mas of the female urethra. Methods：Combined with the review of the literature, study its characteristics by retro spectively analyzing the clinical data of two patients admitted to our hospital from January 2001 to September 2011 who were contracted with schwannomas of female urethra. Results：Both patients turned out to be female, respec- tively at the age of 42 and 48 and were misdiagnosed as urethral caruncle and had a urethral caruncle excision. Af- ter the operation, pathology returned for report that they were actually schwannomas, chemical examination of the immunologic tissue also showed some specificty. A year later, one patient was admitted to hospital again for tumor recurrence to have the urethral tumor resection. Pathological return was low-grade schwannomas and further treat- ment was not taken after the surgery. The patient was in good condition at the present. Conclusions： Urinary schwannomas is very rare clinical disease, and malignant transformation of it is even more rarer. Since the diagnosis of it lacks specificity, it is often misdiagnosed as urethral caruncle, so diagnosis of it relys mainly on pathological and immunohistochemical examination; urethral tumor resection can be used as a treatment method.