乳腺癌患者血清中转移相关蛋白峰的表达及其临床意义

Expression of metastasis-related protein 3 144m/z in breast cancer patients

目的探讨乳腺癌患者血清中转移相关蛋白峰（3144m／z蛋白峰）的表达及其临床意义。方法采用表面加强激光解析电离飞行时间质谱技术检测乳腺癌患者3144m／z蛋白峰的表达，并与CA153水平进行对比分析。结果3144m／z蛋白峰阳性率（30_2％）与CA153阳性率（5．6％）比较，差异有统计学意义（P〈001）；3144m／z蛋白峰阳性率与患者有无淋巴结转移相关（P〈0．05），但与患者的年龄、月经情况、生育情况、流产情况、体重指数、有无家族史、肿瘤大小、肿瘤分子分类、脉管瘤栓、神经侵犯、组织学分级、临床分期、ER和PR表达均无相关性（均P〉0．05）。结论外周血清3144m／z蛋白峰可作为乳腺癌诊断和预后判断的标志物。同时进行血清CA153水平检测，有助于提高淋巴结转移乳腺癌患者的检出率。

Objective To investigate the expression of the 3 144 m/z protein peak in breast cancer patients and its clinical significance. Methods The breast cancer metastasis related protein peak 3 144m/z was detected by SELDI-TOF-MS technique. Its expression level was compared with CA153 in breast cancer patients. Results There was significant difference in positive rate between 3 144m/z protein peak （30.2%） and CA153 （5.6%） （P〈0.01）. The expression of 3 144m/z was correlated with lymph node metastasis（P〈O.05）, but not correlated with the age, menstruation, fertility, abortion, body mass index, family history, tumor size, molecular classification of tumors, vascular invasion, perineural invasion, histological grade, clinical stage, and ER and PR levels （P 〉0.05）. Conclusion Serum 3 144m/z protein may be used as a practical marker for diagnosis and prognosis of breast cancer.