CD147、OPN和MMP-2在口腔鳞状细胞癌中的表达及意义

Expressions and Significances of CD147,OPN and MMP-2 in Oral Squamous Cell Carcinoma

目的研究口腔鳞状细胞癌(OSCC)中基质金属蛋白酶诱导因子(CD147)、骨桥蛋白(OPN)和基质金属蛋白酶-2(MMP-2)的表达和意义。方法采用免疫组化SP法对35例OSCC组织中CD147、OPN和MMP-2的表达进行检测,并分析这3个指标间的相关性。结果 CD147、OPN和MMP-2在OSCC组织中高表达,阳性表达率分别为65.71%、71.43%、68.57%;三者的表达均与OSCC病理分级、临床分期和淋巴结转移有关(P<0.05),而与性别、年龄、生长部位无明显相关性(P>0.05);随着病理分级的降低、临床分期的增高和淋巴结转移,三者的阳性表达率均升高;三者之间的表达互呈正相关(MMP-2和CD147,r=0.653;MMP-2和OPN,r=0.540;CD147和OPN,r=0.381;P均<0.05)。结论 CD147、OPN和MMP-2的表达与OSCC的病理分级及侵袭转移密切相关。

Objective To evaluate the expressions and significances of CD147, OPN and MMP 2 in oral squamous cell carcinoma （OSCC）. Methods The expressions of CD147, OPN and MMP 2 were detected by immunohistoehemical method （SP） in 35 cases of OSCC. The relationships between the expressions of CD147,0PN and MMP 2 and clinic histopathologic parameters of OSCC were analyzed. Results The expression rates of CD147, OPN and MMP 2 in OSCC tissues were 65.71 %, 71. 43% and 68. 57% respectively. The expressions of CD147, OPN and MMP 2 were positively correlated with tumor histopathologic type, clinical stage and lymph node metastasis （P〈0. 05）, but not correlated with age, gender and the location of tumor （P〉0. 05）. The positive correlations were found among the expressions of CD147,OPN and MMP-2 （MMP-2 and CD147,r=0. 653;MMP-2 and OPN,r=0. 540;CD147 and OPN,r=0. 381;P〈0. 05）. Conclusion The expressions of CD147,OPN and MMP-2 increase in OSCC and may be the potential predictor of the malignant degree of OSCC.