期刊文献+

代谢综合征对老年冠心病血运重建患者预后的影响

Impact of Metabolic Syndrome on outcome of revasculization in elderly patients with coronary artery disease
下载PDF
导出
摘要 目的探讨代谢综合征(MS)对冠心病血运重建患者预后的影响。方法选取860例接受血运重建治疗的患者。记录其临床资料、MS各组成成分和随访期间主要不良心血管事件(MACCE)。分别比较老年患者(年龄≥65岁)和非老年患者(年龄〈65岁)随访期间发生MACCE和未发生MACCE患者MS各指标的差别,并采用Logistic回归分析分析MS对老年冠心病血运重建患者再发MACCE的影响。结果(1)老年患者中发生MACCE者79例(25.24%),非老年组患者中发生MACCE者127例(23.22%),差异无统计学意义(P〉005)。(2)老年患者中发生MACCE者与未发生MACCE者LDL的差异有统计学意义(P〈0.05);非老年患者中MACCE组MS所占比例明显高于非MACCE组(P〈0.05)。老年患者中MACCE组糖代谢异常、高BMI及MS所占比例均明显高于非MACCE组(P〈0.05)。(3)HDL及MS是老年冠心病患者发生MACCE的独立危险因素(均P〈0.05)。结论MS是老年冠心病血运重建患者发生MACCE的独立危险因素。 Objective To investigate the impact of metabolic syndrome (MS) on the outcome of revasculization in elderly patients with coronary artery disease (CAD). Methods Eight hundred and sixty patients with CAD who received revasculization therapy were enrolled in the study, including 313 cases aged ≥65 y (elderly group) and 547 cases 〈65 y (control group). The clinical data including MS and major adverse cardiac and cerebral events (MACCE) were retrospectively analyzed and compared between two groups. Logistic regression was used to analyze the risk factors of MACCE after revasculization therapy. Results The incidence rates of MACCE in elderly and control groups were 25,24% (79/313) and 23.22% (127/547), respectively (P 〉0.05). The presence of MS (P=0.014, 0R=3.538, 95%CI 1.297-9.652) was the independent risk factor and HDL level (P=0.038, 0R=0.479, 95%CI 0.239-0.959) was the protective factor for MACCE in the elderly CAD patients following revasculization therapy. Conclusion Metabolic syndrome is a negative factor for outcome of revasculization therapy in elderly patients with cardiovascular disease.
出处 《浙江医学》 CAS 2012年第15期1270-1272,1275,共4页 Zhejiang Medical Journal
关键词 代谢综合征 冠心病 老年 预后 Metabolic syndrome Coronary artery disease The aged Prognosis
  • 相关文献

参考文献4

二级参考文献15

  • 1金文胜,潘长玉.国际糖尿病联盟关于代谢综合征定义的全球共识[J].中华内分泌代谢杂志,2005,21(4):412-413. 被引量:157
  • 2杜小平,万卫民,黎园,杨期东.胰岛素抵抗在动脉粥样硬化性脑梗死与腔隙性脑梗死中的作用[J].中国动脉硬化杂志,2006,14(5):434-437. 被引量:5
  • 3谭静,华琦,闻静,邢绣荣,刘荣坤,杨峥.代谢综合征与动脉僵硬度的关系[J].中国动脉硬化杂志,2006,14(2):167-169. 被引量:20
  • 4HU Rong MA Chang-sheng NIE Shao-ping LU Qiang KANG Jun-ping DU Xin ZHANG Yin GAO Ying-chun HE Li-qun JIA Chang-qi LIU Xin-min DONG Jian-zeng LIU Xiao-hui CHEN Fang ZHOU Yu-jie LU Shu-zheng WU Xue-si.Effect of metabolic syndrome on prognosis and clinical characteristics of revascularization in patients with coronary artery disease[J].Chinese Medical Journal,2006(22):1871-1876. 被引量:9
  • 5Lorenzo C,Okoloise M,Williams K,Stern MP,Haffner SM. The metabolicsyndrome as predictor of type 2 diabetes:the San Antonio heat study[J] .Diabetes Care, 2003, 26 (11) :3153-159 . .
  • 6Kiechl S,Werner P,Egger G,Oberhollenzer F,Mayr M,Xu QB,et al. Active and passive smoking,chronic infections and the risk of carotid atherosclero-sis:prospective results from the Bruneck Study[J] .Stroke, 2002, 33 (9) :2170-176 . .
  • 7St-Pierre AC,Bergeron J,Pirro M,Cantin B,Dagenais GR,Després JP,et al. Effect of plasma C-reactive protein levels in modulating the risk of coronaryheart disease associated with small,dense,low-density lipoproteins in men(TheQuebec Cardiovascular Study)[J] .Am J Cardiol, 2003, 91 (5) :555-558 . .
  • 8Antikainen R,Jousilahti P,Tuomilehto J. Systolic blood pressure,isolated systolic hypertension and risk of coronary heart disease,strokes,cardiovascular disease and all-cause mortality in the middle-aged population[J] .J Hypertens, 1998, 16 (5) :577-583 . .
  • 9Creager MA,Lüscher TF,Cosentino F,Beckman JA. Diabetes and vasculardisease:pathophysiology,clinical consequences,and medical therapy:Part Ⅰ[J] .Circulation, 2003, 108 (12) :1527-532 . .
  • 10Marroquin OC, Kip KE, Kelley DE, et al. Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women' s Ischemia Syndrome Evaluation. Circulation, 2004,109:714-721.

共引文献76

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部