盐酸多奈哌齐对MCI患者MoCA评分和认知功能的影响

Effect of donepezil hydrochloride on changes of cognitive function and Montreal cognitive assessment scores in patients with mild cognitive impairment

目的探讨盐酸多奈哌齐对轻度认知障碍（MCI）患者蒙特利尔认知评估量表（MoCA）评分和认知功能的影响。方法哈尔滨医科大学附属第一医院神经内科自2010年9月至2011年3月共收治MCI患者50例，其中给予盐酸多奈哌齐治疗30例（盐酸多奈哌齐组），银杏叶片治疗20例（对照组），分析并比较2组患者治疗前、治疗12周、24周后MoCA评分的变化。结果盐酸多奈哌齐组患者治疗12、24周时MoCA评分高于治疗前，差异有统计学意义（P〈0．05）。治疗12周、24周时盐酸多奈哌齐组MoCA评分均高于对照组，差异有统计学意义（P〈0．05）；治疗12周时盐酸多奈哌齐组患者在数字广度、词语流畅性和延迟记忆方面的分项得分高于治疗前．差异有统计学意义（P〈0．05）。结论MoCA量表能够对MCI患者进行早期诊断，盐酸多奈哌齐对MCI患者进行早期治疗能延缓其进入AD的病程。

Objective To investigate the effect of donepezil hydrochloride on changes of cognitive functions and Montreal cognitive assessment （MoCA） scores in patients with mild cognitive impairment （MCI）. Methods A total of 50 patients diagnosed as having MCI, admitted to our hospital from September 2010 to March 2011, were recruited; these patients were randomly assigned into treatment group （treated with donepezil hydrochloride, n=30） and control group （treated with Ginkgo biloba, n=20）; the changes of MoCA scores were noted at 12 and 24 weeks after treatment. The data were analyzed by the statistical software SPSS 10.0. Results MoCA scores of treatment group 12 and 24 weeks after treatment were significantly higher than those before treatment （P〈0.05）; MoCA scores of treatment group were significantly higher than those of control group 12 and 24 weeks after treatment （P〈0.05）. Mann-Whitney rank sum test showed significant improvement in digit span, verbal fluency and delayed memory after the treatment of donepezil hydrochloride for 12 weeks as compared with those before treatment （P〈0.05）. Conclusion By MoCA scale, MCI patients could get early diagnosis; MCI patients with early diagnosis and early application of donepezil hydrochloride will delay their entry into the course of AD.