一种新型不对称马来酰亚胺单体的合成

Synthesis of A Novel Optical N-substituted Maleimide(AMI)

以马来酸酐 (MA) ,D ,L 氨基丙酸 (Aln)为原料合成了一种既含不对称碳原子又含官能团 (羧基 )的新型马来酰亚胺单体N (异丙酸基 ) 马来酰亚胺 (AMI)。考察了溶剂、原料配比、催化剂用量、反应时间对产率的影响 ,确定了最佳反应条件。所得N (D ,L 异丙酸基 )马来酰亚胺的产率达 52 %。并用PERKIN ELMERFTIR 1 71 0红外光谱仪、PE 2 4 0 0有机元素分析仪对产品进行了检测。本实验具有产率高、溶剂易回收、AMA不需纯化等优点。

N (D,L alaninyl) maleimide was synthesized from D,L alanine and maleic anhydride. The effects of solvent, raw material ratio, amount of catalyst and reaction time on the yield were investigated. The product was characterized with FT IR and element analytical instrument. The most optimum conditions were obtained. The yield of AMI can be up to 52%. This technology has some advantages: solvent was recovered easily, AMA didn't need to be purified and high yield.