以枸骨叶为原料提取熊果酸工艺的研究

Study on extraction process of ursolic acid from Ilex Aqujfolium L. leaf

采用正交实验筛选出从枸骨叶中提取熊果酸的最佳工艺。当使用 85%～ 95%乙醇提取两次、每次 80min时 ,对干枸骨叶的提取率达到 90 %。在后处理中使用 2 .5倍于沉淀物质量的石油醚洗涤 3次 ,最后使用乙醇重结晶得到产品。

The optimal process for extracting ursolic acid from Ilex Aquijfolium L. leaf is selected by using orthogonal test. The extraction rate of ursolic acid from dry Ilex Aqujfolium L. leaf reaches 90% when the extraction is conducted twice using 85%～90% ethanol for 80min each time. The final product is obtained after washing by petroleum ether 2.5 times of the precipitated material for three times and re crystallization by ethanol.