B细胞激活因子与过敏性紫癜相关性研究

Study on association of BAFF and Henoch-schonlein purpura

目的:通过分析B细胞激活因子(BAFF)与患者免疫球蛋白在不同类型过敏性紫癜(HSP)中的表达,初步探讨BAFF在过敏性紫癜免疫发病机制中的作用。方法:收集HSP活动期患者,包括皮肤型30例、关节型30例、腹型32例、肾型31例、混合型41例,将健康人40例作为对照组。速率散射比浊法测定免疫球蛋白水平;ELISA方法检测BAFF蛋白含量。结果:IgA仅在混合型HSP中增高,IgG和IgM在各组中并无增高;不同类型HSP活动期患者血清中BAFF表达水平均明显高于对照组;混合型HSP患者血清中BAFF表达水平与同型患者IgA表达水平呈中等程度的相关性。结论:BAFF与HSP发病时的体液免疫增强有关。

Objective：To observe the level of BAFF and immunoglobulin in different subtypes of Henoch-schonlein purpura（HSP）,and to explore the role of BAFF in the pathogenesis of HSP.Methods：Active HSP patients were collected,including skin group（n=30）,joint group（n=30）,abdominal group（n=32）,kidney group（n=31）,mixed group（n=41）,40 healthy people were chose as control group.The level of immunoglobulin was examined with Rate Nephelometry and ELISA method was used to detect BAFF.Results：The level of IgA was higher in mixed group than in control group,IgG and IgM did not increase in HSP;different subtypes of HSP patients expressed significantly higher level of BAFF in serum than the control group;the expression of serum BAFF moderately associated with the level of IgA in mixed group.Conclusion：BAFF was related to enhancement of humoral immunity when HSP was in onset.