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IL-17与肿瘤的关系 被引量：5

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摘要 1863年,R.Virchow基于肿瘤常常发生在慢性炎症部位和炎症细胞往往出现在肿瘤组织中的事实,提出了慢性炎症和肿瘤发生相关的假说[1]。随着近些年来研究的深入,该理论已被广泛接受。肿瘤细胞通过产生各种细胞因子和趋化因子来募集白细胞（包括中性粒细胞、树突状细胞、巨噬细胞、嗜酸性粒细胞、嗜碱性粒细胞和淋巴细胞）,这些白细胞通过产生一系列的细胞因子和炎症介质参与肿瘤免疫[1]。
作者 钱鑫 杜娇 金阳
机构地区 华中科技大学同济医学院附属协和医院呼吸内科卫生部呼吸疾病重点实验室
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2012年第8期760-765,768,共7页 Chinese Journal of Immunology
基金 国家自然科学基金资助项目(81072400) 武汉市科技计划资助项目(20116103834001)
关键词 肿瘤组织 IL-17 嗜酸性粒细胞 嗜碱性粒细胞 慢性炎症 细胞因子 中性粒细胞 树突状细胞
分类号 R392.12 [医药卫生—免疫学]
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参考文献49

  • 1C oussens L M, Werb Z. Inflammation and cancer [ J ]. Nature,2002 ; 420(6917) :860-867.
  • 2Onishi R M,Gaffen S L. Interleukin-17 and its target genes:mecha- nisms of interleukin-17 function in disease [ J]. Immunology, 2010; 129(3) :311-321.
  • 3Rouvier E, Luciani M F, Matt6i M Get al. CTLA-8, cloned from an activated T cell, beating AU-rich messenger RNA instability sequences,and homologous to a herpesvirus saimiri gene [ J ]. J Immu- no1,1993 ;150(12) : 5445-5556.
  • 4Yao Z, Painter S L, Fanslow W C et al. Human IL-17 : a novel cyto- kine derived from T ceils [ J]. J Immunol, 1995; 155 ( 12 ) : 5483- 5486.
  • 5Gaffen S L. An overview of IL-17 function and signaling [ J]. Cyto- kine ,2008 ;43 ( 3 ) :402-407.
  • 6Fossiez F, Djossou O,Chomarat Pet al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines [J]. J Exp Med,1996;183(6) :2593-2603.
  • 7Kom T,Bettelli E,Oukka Met al. IL-17 and Thl7 cells [Jl. Annu Rev Immuno1,2009 ;27:485-517.
  • 8Takeuchi A, Dejima T, Yamada H et al. IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis ba- cillus Calmette-Guerin treatment against bladder cancer [ J ]. Eur J Immunol,2011 ;41 ( 1 ) :246-251.
  • 9Wakita D, Sumida K, Iwakura Y et al. Tumor-infiltrating IL-17-pro- ducing γδT cells support the progression of tumor by promoting angio- genesis [ J]. Eur J Immunol,2010 ;40(7) : 1927-1937.
  • 10Yao Z, Spriggs M K, Derry J Met al. Molecular characterization of the human interleukin (IL)-17 receptor [J]. Cytokine, 1997;9 (11) :794-800.

同被引文献47

  • 1顾龙君.儿童急性淋巴细胞白血病诊疗建议(第三次修订草案)[J].中华儿科杂志,2006,44(5):392-395. 被引量：476
  • 2Giatromanolaki A, Bates G, Koukourakis M, et al . The presence of tumor-infiltrating FOXP3 + lymphocytes correlates with intratumoral angiogenesis in endometrial cancer[j]. Gynecol Oncol, 2008,110: 216-221.
  • 3deJong RA, Leffers N, Boezen HM, et al . Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer[J]. Gynecol Oncol , 2009.114: 105-11 O.
  • 4Sawan S, Burt DJ, Stern PL, et al. Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status[J]. Immunol Invest, 2011,40: 6Z-75.
  • 5Shevach EM. Mechanisms of Foxp3+ T regulatory cell-mediated suppression[J]. Immunity, 2009,30: 636-645.
  • 6FontenotJD, RasmussenJP, Williams LM. et al. Regulato- ry T cell lineage specification by the forkhead transcription factor Foxp3[J]. Immunity. 2005,22: 329-341.
  • 7Roncador G, Brown PJ, Maestre L, et al . Analysis of FOXP3 protein expression in human CD4( + )CD2S( +) regulatory T cells at the single-cell level[J]. EurJ Imrnunol , 2005,35: 1681-1691.
  • 8Tano T. Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augmentation of OK-432-induced helper T cell 1 response by 5-FU and X-ray irradiation[J]. Neoplasia, 2013, 15: 805-814.
  • 9Ma GF. Foxp3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating the apoptotic signaling pathway[}]. Biochem Biophy Res Comrnun , 2013, 430: 804- 809.
  • 10Yamagami W, Susumu N. Tanaka H, etal. Immunofluorescence-detected infiltration of CD4 + Foxp3 + regulatory T cells is relevant to the prognosis of patients with endometrial cancer[J]. IntJ Gynecol Cancer, 2011, 21: 1628-1634.

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中国免疫学杂志
2012年 第8期

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