血清CysC、Hcy、及β-HCG检测与妊娠期高血压疾病的相关性研究

The correlation study of serum cystatin C,Hcy,and beta-HCG testing and hypertensive disorder complicating pregnancy

目的探讨孕妇血清半胱氨酸蛋白酶抑制剂C(Cystatin C)、同型半胱氨酸(Hcy)、及β-HCG联合检测与妊娠期高血压疾病的相关性。方法选择健康晚孕妇女60例及妊娠期高血压疾病(hypertensive disorder complicating preg-nancy,HDCP)患者肾病组18例和妊娠期高血压疾病患者无肾病组35例,对其血清分别进行Cys C、Hcy、β-HCG的检测。结果妊娠期高血压疾病肾病组血清Cys C、Hcy水平明显高于无肾病组(P<0.01),两组均明显高于健康晚孕组(P<0.01);妊娠期高血压疾病肾病组及无肾病组β-HCG水平无明显差别(P>0.05),与健康晚孕组比较结果有统计学意义(P<0.05)。结论血清Cys C、Hcy与β-HCG联合检测对了解妊娠期高血压疾病的病情具有重要意义。Cys C及Hcy与β-HCG比较在反映HDCP患者的肾损害及肾功能恢复方面更敏感,是反映HDCP病情及预后的良好指标。联合检测可作为了解HDCP的发生、发展及预后判断的指标。

Objective ： Investigate the correlation of maternal serum Cystatin C, homocysteine （ Hcy）, β - HCG Joint detection and hypertensive disorder complicating pregnancy （HDCP）. Methods： Choose 60 cases of healthy late pregnant women, 18 cases of HDCP with kidney disease, and 35 cases of HDCP without kidney disease. Test the serum Cys C, Hey, β- HCG. Results ： The levels of serum Cys C and Hcy in group of HDCP with kidney disease are significantly higher than the group of HDCP without kidney disease （ P 〈 0. 01 ）. These two groups are significantly higher than the group of healthy late pregnant women （ P 〈 0. 01 ）. There is no significant difference between β - HCG＇s level of group of HDCP with kidney disease and group of HDCP without kidney disease （P 〉 0. 05 ）. The results are statistically significant that the two groups compare with the healthy late pregnant group （ P 〉 0. 05 ）. Conclusion ： Joint detection of serum Cys C, Hcy, and β - HCG has great significance to understand the condition of HDCP. Comparison of Cys C, Hcy and β - HCG is sensitive in the respect of renal injury and renal function recovery, that is a good index to reflect the condition and prognosis of HDCP. The joint detection can be used as the indicator of occurrence, development and prognosis of HDCP.