摘要
目的研究ABO血型不合溶血病合并葡萄糖-6-磷酸脱氢酶(G-6-PD)缺陷症的新生儿高胆红素血症(简称高胆)的发病特点。方法选择2007年1月至2010年12月收治母婴ABO血型不合新生儿溶血病合并G-6-PD缺陷症11例(A组)与同期单纯ABO血型不合溶血病80例(B组)新生儿高胆进行分析。结果①91例母婴ABO血型不合溶血病的新生儿中合并G-6-PD缺陷症11例(12.1%)。②新生儿高胆发病日龄:两组均以1~2 d为主(A组9例占81.82%,B组67例占83.75%);高峰日龄:两组均以2~3d为主(A组9例占81.82%,B组73例占91.25%);消退时间:两组均在<6天内。发病日龄、高峰日龄、消退时间经统计学分析各组之间均无显著差异(P>0.05)。③新生儿贫血程度:两组之间中度贫血无显著差异(P>0.05),但轻度贫血及血红蛋白正常者组,经统计学分析差异极显著(P<0.01)。结论 11例母婴ABO血型不合溶血病合并G-6-PD缺陷症新生儿:①母婴ABO血型不合溶血病中合并有G-6-PD缺陷症的几率为12.1%。②高疸发病日龄基本在1~2d内,高峰日龄基本在2~3d内,消退时间均在<6天内,与单纯ABO血型不合溶血病基本相同。③新生儿轻度贫血较单纯ABO血型不合溶血病明显,表明溶血会加重,但只要早期诊断、早期干预,预后良好。
Objective : To investigate the pathogenesis characteristics of hyperbilirubinemia of the newborn with ABO blood type incompatible hemolytic disease and G6PD deficiency. Methods: Choose 11 cases hyperbilirubinemia of the newborn with ABO blood type incompatible hemolytic disease and G6PD deficiency ( A group) and the corresponding period 80 cases hyperbilirnhinemia of the newborn only with ABO blood type incompatible hemolytic disease (B group) between January 2007 and December 2010 and analyze. Results: (1) In 91 cases newborn with ABO blood type incompatible hemolytic disease, there are 11 cases simultaneously with G6PD deficiency ( 12. 1% ). (2) The age in days of the hyperbiiirubinemia happening of the newborn: both groups most arc at 1 st -2nd day (A group 9 cases taken up 81.82% , B group 67 cases taken up 83.75% ) ; The peak age in days of the hyperhiliruhinemia: both groups most are at 2nd -3th day (A group 9 cases taken up 81.82% , B group 73 cases taken up 91.25% ) ; Vanish time: both groups 〈6 days. There is no significant differences between two groups at the age in days of the hyperbilirubinemia happening, the peak age in days and vanish time ( P 〉 0. 05). (3) The degree of anemia of the newborn : There is no significant differences of moderate anemia between two groups (P 〉 0. 05). There is significant differences of mild anemia and normal haemoglobin (P 〈0. 01 ). Conclusions: 11 cases newborn with ABO blood type ineompatible hemolytic disease and G6PD deficiency. (1) The incidence of ABO blood type ineompatible hemolytie disease of the newborn together with G6PD deficiency is 12. 1%. (2)The age in days of the hyperbilirubinemia happening most are at 1st -2nd day; The peak age in days of the hyperbilirubinemia most are at 2nd -3th day; All the vanish time within 6 days. It is similar with merely ABO blood type ineompatible hemolytic disease. (3) Mild anemia of the newborn is obvious compare with merely ABO blood type ineompatible hemolytie disease, showing that hemolysis will aggravate. Prognosis would be fine if diagnosis early and intervention early.
出处
《中国优生与遗传杂志》
2012年第9期81-82,共2页
Chinese Journal of Birth Health & Heredity
关键词
高胆
ABO血型不合
G-6-PD缺陷症
新生儿
Hyperbilirubinemia
ABO blood type incompatible hemolytic disease
G6PD deficiency
Newborn