纳米结构分子印迹聚合物及其在药物分析中的应用进展

Research and Application of Nanostructured Molecularly Imprinted Polymers in Pharmaceutical Analysis

纳米材料是纳米技术发展的重要基础,它具有许多传统材料所不具备的独特的理化性质,因此有着广泛的应用前景。分子印迹技术是一种通过模拟抗体-抗原相互作用原理,制备具有分子识别功能的聚合物的技术。以纳米材料制备的分子印迹聚合物具有较高的结合容量,较大的选择性和较快的结合动力学特性,近年来备受关注。本文简单概述了零维、一维、二维纳米结构分子印迹聚合物的合成、表征方法及研究现状,并对其在手性药物分析、临床药物分析、传感器及药物残留检测中的应用进行了综述。

Nanotechnology is an emerging technology with enormous potential due to their specific structures and properties that differ from traditional materials. Molecularly imprinting is a technique for the preparation of polymers of predetermined specificity based on imitating the way of interaction between antigen and antibody. Compared to conventional molecularly imprinted polymer, nanostructured molecularly imprinted polymer has many advantages： high afinity and selectivity, more accessible sites, fast association kinetics. Thus, nanostruetured molecularly imprinting technique receives more and more attention by scientific researchers in recent years. This review covers the synthesis, characterization and latest advances of zero-dimensional （0-D）, one-dimensional （1-D） and second-dimensional （2-D） nanostructured molecularly imprinted polymer. Moreover, the application of nanostructured molecularly imprinted polymer in the fields of chiral separation, clinical pharmaceutical analysis, sensor technology and drug residue detection were reviewed.