2-(氨基)乙基甲基砜盐酸盐的合成

Synthesis of 2-Aminoethylmethylsulfone Hydrochloride

甲基亚磺酸锌二水合物(2)与环氧乙烷经开环、氯代、取代及水解反应制得2-(氨基)乙基甲基砜盐酸盐(1),总收率50%。2或甲基亚磺酸钠与N-(2-溴乙基)邻苯二甲酰亚胺经取代和水解反应也可制得1,总收率68%或79%。

2-Aminoethylmethylsulfone hydrochloride （1） was synthesized from zinc methanesulfinate dihydrate by reaction with ethylene oxide, chlorination, substitution and then hydrolysis with the overall yield of 50%. The compound 1 was also prepared from zinc methanesulfinate dihydrate or sodium methanesulfinate by substitution with N- （2-bromoethyl） phthalimide and then hydrolysis with the overall yield of 68 % and 79 %, respectively.