数值模拟在片剂制备中的应用

Application of Numerical Simulation to Tablet Formation

片剂稳定性好,对温度和湿度变化有良好的耐受性,是最常见的剂型。片剂制备技术是制药行业关键技术之一,很多研究考察了片剂制备过程的重要参数和影响粉末流动性的因素。但压片过程包括复杂的颗粒流动过程,机器的结构设计和粉末微观、宏观的变化等一系列问题,一般的实验研究难以解决此类问题。随着计算机技术的迅速发展,数值模拟方法逐渐成为研究压片过程的有效工具。本文汇总了采用数值模拟方法研究片剂制备过程(充填过程和压片过程)的文献,探讨了该方法在片剂制备中的应用。

Tablet has good stability and tolerance to changes of temperature and humidity so that it is the most common dosage form. The tablet formation technology is one of the key techniques in the pharmaceutical industry. There are many researches on the important parameters of the tablet preparation process and influence factors on powder fluidity. However, tabletting process includes a series of problems, such as the complex flow of powder, structural design of machine, microscopic and macroscopic changes of powder. Common studies are difficult to solve above problems. With the rapid development of computer technology, numerical simulation is becoming an effective tool in the tabletting process. The literatures on tablet preparation process （the process of filling and tabletting） with numerical simulation method are summarized in this paper. The application of numerical simulation to tablet formation is discussed.