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hTERT基因多态性与食管癌的相关性 被引量：1

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摘要 目的研究中国汉族人群中人端粒酶逆转录酶(human telomerase-reverse transcriptase,hTERT)基因多态性与食管癌发生危险的关系。方法用高分辨率熔解曲线(high resolution melting,HRM)法分析384例食管癌和384例非肿瘤患者hTERT基因多态性,计算各种基因型的食管癌发生风险及其95%可信区间(CI)并进行遗传平衡检验。结果 hTERT rs2735940 C>T3种基因型CC、CT、TT在食管癌组和非肿瘤组的频率分别为41.0%(CC)、44.1%(CT)、14.9%(TT)和37.0%(CC)、45.9%(CT)、17.1%(TT)。与CC基因型个体相比较,TT型与食管癌的发病风险无明显相关(调整OR=0.79,95%CI=0.52～1.21)。结论 hTERT rs2735940 C>T基因多态性可能不是食管癌发生的易感因素。
作者 马少君 刘超 顾海勇 唐巍峰 董长青 丁国文 陈锁成
机构地区 江苏大学附属人民医院胸外科
出处 《临床检验杂志》 CAS CSCD 北大核心 2012年第8期614-616,共3页 Chinese Journal of Clinical Laboratory Science
关键词 人端粒酶逆转录酶 食管癌 高分辨率熔解曲线 单核苷酸多态性
分类号 R735.1 [医药卫生—肿瘤]
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临床检验杂志
2012年 第8期

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