新生儿非典型微生物感染性肺炎病原及疗效分析

Pathogen distribution and therapeutic efficacy of atypical neonatal pneumonia

对682例日龄≥4d的新生儿感染性肺炎进行病原学检测，其中非典型病原微生物检测结果阳性167例（24．49％）。167例新生儿非典型性肺炎中沙眼衣原体、解脲支原体、肺炎衣原体和肺炎支原体检出阳性者分别为124例（74．25％）、55例（32．93％）、47例（28．14％）和35例（20．96％），差异有统计学意义，X^2=116．33，P〈0．01。167例患儿母亲沙眼衣原体阳性率为80．84％，解脲支原体为53．29％，肺炎衣原体为50．90％，肺炎支原体为53．29％。应用阿奇霉素抗感染及其他综合治疗，结果治愈151例，有效11例，总有效率97．01％，治疗前后肝肾功能无改变。提示非典型病原微生物是新生儿感染性肺炎中常见的病原微生物；新生儿非典型肺炎以沙眼衣原体感染最多，肺炎支原体感染率相对较低；患儿母亲为直接病原传播者；阿奇霉素对其疗效安全可靠。

The pathogens were tested in 682 cases of neonatal pneumonia, atypical pathogens were found in 167 cases （24.49%）. Among the 167 cases, chlamydia trachomatis was detected in 124（74.25% ）, ureaplasma urealyticum in 55 （32. 93% ）, chlamydia pneumoniae in 47 （28.14%） and mycoplasma pneumoniae in 35 （20. 56% ）. The Chlamydia trachomatis-positive rate in mothers of 167 cases was 80. 84% , ureaplasma urealyticum was 53.29% , chlamydia pneumoniae was 50. 90% , Mycoplasma pneumoniae was 53.29%. The patients were treated with azithromycin and other antibiotics, 151 cases were cured and 11 were effective with an overall efficacy rate of 97.01%. The liver and kidney function were tested before and after treatment; and there were no significant changes after treatment. The results show that azithromycin is safe and effective for treatment of neonatal infectious pneumonia from atypical pathogens.