血清Hcy与Hs-CRP联合检测在心脑血管疾病中的应用

Application of combined detection of serum homocysteine and Hs-CRP to diagnosis of cardio-cerebrovascular disease

目的探讨血清同型半胱氨酸(Hcy)、超敏C-反应蛋白(Hs-CRP)水平与脑卒中、冠心病的关系,评价Hcy、Hs-CRP测定对脑卒中、冠心病的临床价值。方法 Hcy测定采用酶法,Hs-CRP测定采用比浊法,对349例脑卒中(其中脑出血158例,脑梗死191例)、124例冠心病患者进行检测,并与113例健康体检者进行比较。结果脑卒中组与冠心病组Hcy、Hs-CRP的水平均高于健康对照组(P<0.05),脑出血组与脑梗死组比较无明显差异(P>0.05)。结论脑卒中与冠心病患者血清Hcy、Hs-CRP水平明显增高,Hcy、Hs-CRP联合测定对脑卒中、冠心病的早期诊治和预后判断均有重要价值。

Objective To discuss the correlation between the levels of serum homocysteine （Hcy） and hypersensitive C - reactive protein and stroke and coronary heart disease （ CHD）, and to evaluate the clinical value of combined detection of Hcy and Hs - CRP for those diseases. Methods 349 patients with stroke （ 158 patients with cerebral hemorrhage and 191 ones with cerebral infarction） and 124 patients with CHD received the detection of Hcy by enzymic method and the detection of Hs - CRP by turbidimetry. And their detected results were compared with those of other 113 healthy persons. Results The levels of Hcy and Hs - CRP in the stroke group and the CHD group were higher than those in the healthy control group （P 〈 0.05 ）. There was no significant difference between the cerebral homorrhage patients and the cerebral iiffarction ones （ P 〉 0. 05 ）. Conclusion The levels of Hey and Hs - CRP in patients with stroke and CHD increase significantly. The combined detection of Hey and Hs - CRP has an important value in the early diagnosis, treatment, and prognostic judgment of stroke and CHD.