5-羟色胺转运蛋白基因多态性与脑卒中后抑郁的关联

Correlation of serotonin transporter gene polymorphism with post-stroke depression

目的:探讨5-羟色胺转运体连锁启动区(5-hydroxytryptamine transporter linked promoter region,5-HTTLPR)基因多态性与脑卒中后抑郁发病、自杀行为是否相关。方法:应用聚合酶链反应(PCR)扩增技术测定中国汉族脑卒中抑郁(poststroke depression,PSD)患者90例(PSD组)和无抑郁脑卒中患者90例(非PSD组)的5-HTTLPR基因型及等位基因,分别验证各种基因型与脑卒中抑郁症发病及自杀行为的相关性。结果:PSD组SS基因型及S等位基因频率(64.4%,75.6%)明显高于非PSD组(38.9%,58.3%),S等位基因携带者PSD患病率为LL型纯合子的1.29倍(OR=1.29,P<0.001,95%CI:1.11～1.50);对PSD组自杀行为分层比较,有自杀行为组SS基因型及S等位基因频率(76.8%,75.6%)明显高于无自杀行为组(44.1%,58.3%),PSD患者中,S等位基因携带者自杀行为发生概率为LL纯合子的1.3倍(OR=1.3,P<0.01,95%CI:1.08～1.6)。结论:5-HTTLPR基因可能是PSD的易感基因,S等位基因可能与PSD及自杀行为相关。

To determine the association of polymorphism in the 5-hydroxytryptamine transporter-linked promoter region（S-HTTLPR） with episodes of suicidal behavior in post-stroke depression （PSD） in Chinese Han people. Methods： Polymerase chain reaction （PCR） was used to detect the distribution frequency of 5-HTTLPR polymorphisms from 90 PSD patients （PSD group） and from 90 stroke patients without depression （non-PSD group）. Results： The frequency of the SS genotype and S allele in PSD group was higher than that in the nonPSD group （64.4% vs 38.9%; 75.6% vs 58.3%）. The prevalence of S allele carriers was higher than that of the LL genetpye carriers（OR=1.29, P〈0.001; 95%CI： 1.11-1.50）. The frequency of SS genetype and S allele were different between the PSD patients with suicidal behavior and those without （76.8% vs 44.1%; 75.6% vs 58.8%, repectively）. S allele carriers had a higher suicide rate than LL genotpye carriers（OR= 1.3, P〈0.01j 95%CI： 1.08-1.6）. Conclusion： The 5-HTTLRP gene may be a risk factor of PSD, and S allele may be associated with PSD and suicidal behavior.