脂肪组织巨噬细胞与胰岛素抵抗关系的研究进展

Adipose tissue macrophages and insulin resistance

脂肪组织除了能够储存能量,还能过度分泌各种细胞因子,促使巨噬细胞大量募集,而募集的巨噬细胞进一步分泌各种炎性因子作用于脂肪细胞,二者互相作用导致慢性炎症发生。肥胖相关的脂肪细胞肥大、慢性炎性状态以及脂肪组织异常分化是导致胰岛素抵抗的重要原因。巨噬细胞大量浸润脂肪组织是脂肪组织慢性炎性反应的重要标志。

It has been found that,in addition to storing energy,adipose tissue can also secret numerous cytokines.Importantly,many studies have shown that these cytokines directly induce macrophage infiltration of adipose tissue.It is likely that the dynamic interplay of cytokines and macrophages underlies the pathophysiology of chronic inflammation.Adipocyte hypertrophy,chronic inflammation and the dedifferentiation of adipocytes may play a key role in obesity-related insulin resistance（IR）.Consequently,macrophage infiltration of adipose tissue is an important marker of chronic inflammation of adipose tissue.