2260例静脉注射海洛因依赖者HBV、HCV感染状况分析

A Study on HBV HCV Infection in 2260 Cases with Intravenous Injection Heroin Addicts

应用ELISA法对 2 2 6 0例iv海洛因依赖者进行血清HBsAg、抗 -HCV、ALT检测。结果表明 ,iv海洛因依赖者血清HBsAg、抗 -HCV阳性率分别为 37 8%、53 9% ,HBsAg、抗 -HCV同时阳性者 4 56例 ,重叠感染率 2 0 2 %均显著高于对照组 (2 4 9%、2 2 3%、10 8% )。两组之间的差异有非常显著性 (均P <0 0 0 1)。在 2 2 6 0例iv海洛因依赖者中 ,HBV、HCV单纯感染者 ,ALT异常率分别为2 6 3%、59 6 % ,两者比较差异有非常显著性 (P <0 0 0 1)。HBV HCV重叠感染者ALT异常率6 2 1% ,与HBV单纯感染者比较 ,差异有非常显著性 (P <0 0 0 1) ,与HCV单纯感染者比较 ,差异无显著性 (P >0 0 5)。在iv海洛因依赖者中 ,HCV感染率较HBV感染率更高 ,抗 -HCV阳性者 ,ALT异常率高于HBsAg阳性者。提示iv毒品传播HCV已成为一种不可忽视的重要途径。

In order to understand the status of HBV HCV infection in intravenous injection heroin addicts ,HBsAg,anti-HCV and ALT in serum were detected by ELISA in 2260 cases of intravenous injection heroin addicts .The Results showed that the positive rates of HBsAg and anti-HCV in serum were 37.8% and 53.9% respectively and 456 cases of both HBsAg and anti-HCV positive were found with a coinfection rate of 20.2%, all of them were significantly higher than those in the control groups ( 24.9% ,22.3%,10,8%).There was a statistic difference between two groups (P<0 001).In the group of 2260 cases of heroin addicts, the infection rate of HBV or HCV only and abnormal rate of ALT were 26.3% and 59.6%, respectively and there was a statistic difference between two groups (P<0 001).The abnormal rate of ALT in HBV HCV coinfection patients was 62.1%, (P<0.001) when compared with HBV infection group and there was no significant difference when compared with HCV infection only (P>0 05). Conclusion: In intravenous injection heroin addicts, the infection rate of HCV was higher than that of HBV and the abnormal rate in anti-HCV positive patients was higher than that in HBsAg positive patients. It was suggested that intravenous injection has become an important way for spreading.