帕罗西汀治疗抑郁性神经症临床研究

A study of paroxetine in the treatment of depressive neurosis

目的 :评价帕罗西汀对抑郁性神经症的疗效和副作用。 方法 :对 74例患者分别以帕罗西汀与氯丙咪嗪治疗 ,用汉密尔顿抑郁量表 ( HAMD) ,汉密尔顿焦虑量表 ( HAMA) ,不良反应症状量表 ( TESS)评定疗效和副作用。 结果 :两组疗效、减分率比较无显著差异 ( P>0 .0 5) ,但帕罗西汀副作用少而轻 ,服药简便 ,依从性好。 结论 :帕罗西汀是一种安全 ,有效的新一代抗抑郁剂。

Objective:To compare the efficacy and side effect of paroxetine and clomipramine in the treatment of depressive neurosis. Method:Seventy four subjects with the diagnosis of depressive neurosis were randomly treated with paroxetine or clomipramine for eight weeks. The clinical response and side effects were monitored with the HAMD, HAMA and TESS. Results:There was no significant difference in the therapeutic response between the two treatment groups but the subjects on paroxetine significantly experienced fewer side effects and had better compliance because of the simple drug regime. Conclusion:Paroxetine is an effective and safe antidepressant.