宫颈感染解脲支原体与不良妊娠结局的关系

The relationship between cervical Ureaplasma urealyticum infection and adverse pregnancy outcomes

目的 :探讨宫颈解脲支原体 (UU)在不同状态下与不良妊娠结局的关系。方法 :通过聚合酶链反应 (PCR)对 2 10例孕妇的宫颈分泌物进行uuDNA检测 ,用酶联免疫吸附试验 (ELISA)检测孕妇血清抗uuIgM ,,以两项检测结果同时阳性做为宫颈uu感染的标准 ,以uuDNA阳性而血清抗uuIgM阴性做为宫颈uu的携带状态的标准。结果 :2 10例孕妇中宫颈分泌物uuDNA阳性 10 0例 ,占 47.6 % ,宫颈分泌物uuDNA及血清抗uuIgM均为阳性者 6 2例 ,占分娩总数的 2 9.5 % ,占宫颈分泌物阳性者的 6 2 % ;感染组分别与携带组和阴性对照组比较 ,胎膜早破、早产、剖宫产、新生儿窒息、低体重儿、新生儿肺炎、绒毛膜羊膜炎等不良妊娠结局的发生率明显升高 ,差异显著 (P <0 .0 5 ) ,而携带组与阴性对照组相比 ,无显著差异 (P >0 .0 5 )。结论 :宫颈uu发生感染与不良妊娠结局的发生密切相关 ;正常携带状态与其无相关性 ;

Objectives:To explore the relationship between the adverse pregnancy outcoumes and the different status of cervical Ureaplasma urealyticum (carried and infection).Methods:In this study,polymerase chain reaction (PCR) was used to examine uuDNA at cervical secrete,ELISA was used to examine two handred and ten asymptomatic pregnant women serum antibody to uu(i.e.uuIgM).Only did both results present positive that the infection of cervical uu occured,carried status was defined as cervical uuDNA positive and uuIgM negative.Disscusse was based on the relationship between the different status(carried and infection)and adverse pregnancy outcomes.Results:100 of 210(47.6%) patients with uuDNA positive,62 of 210(29.5%)patients with uuDNA and uuIgM positive.The infected group had a significantly higher rate of premature rupture of membranes (PROM),preterm labour,cesarean section,fetal distress,low birth weight,postpartum haemorrhage and chorioamnionitis(CMA)than the carrying group and the control group respectively (P<0.05).There were no significant difference between the carrying group and the control group on the adverse pregnancy outcomes (P>0.05).Conclusion:There is consistent correlation between cervical Ureaplasma urealyticum infection and the adverse pregnancy outcomes.The mechanism of cervical uu leading to the adverse pregnancy outcomes in chorioamnionitis.