摘要
本文观察了一组行滤过术的病人，以了解ＭＭＣ在青光眼滤过术后抗瘢痕形成的远期疗效．方法：原发性晚期青光眼 ５２例（６２只眼），其中开角型 １０例（１４ 只眼），慢性闭角型青光眼３６例（４０只眼）及以往行青光眼滤过术失败者 ６例（８只眼）． ＭＭＣ组（３２只眼），对照组（３０只眼）．在小梁切除术中一次使用含０．４ｍｇ／ｍｌＭＭＣ棉片置于球结膜／筋膜与巩膜间４分钟，对照组不使用ＭＭＣ．术后追踪观察１４个月（６个月～２４个月）．结果：功能性滤过泡ＭＭＣ组９６．８％，对照组６０．０％（Ｐ＜０．００５）； 手术成功率（ＩＯＰ≤２．８ｋＰａ，２１ｍｍＨｇ；不加用药物ＭＭＣ９３．７％，对照组２６．６％（Ｐ＜０．００５）。随机分为ＭＭＣ组低眼压性黄斑水肿５只眼、滤过泡渗漏１只眼，白内障１只眼，对照组未发现并发症。结论： ＭＭＣ具有明显抑制青光眼滤过术后瘢痕形成的作用，手术成功率明显提高，但术后可出现某些并发症。
Objective: To evaluate the long-term effect in a group of patients with galucoma after trabeculectomy with mitomycin-C intraoperatively. Methods: 52 cases (62 eyes) of primal glaucoma in late stage were divided into MMC group and control group randomly including 10 cases of open angle glaucoma 36 cases of closed angle glaucoma and 6 cases of glaucoma that failed in previous filtering operation. MMC group was treated with 0.4mg/ml MMC during operation after conjunctival flap was performed. A5×6mm sponge with MMC was placed between the conjunctival flap and the sclera for four minutes. All patients were followed up 14 months (6-14 months). Results: The functional bleb rate 96.8% IMMC group and 60.0% in the control group (p<0.05). The result that intraocular pressure was less than 21mmHg without medicine was 93.7% in MMC group and 26.6% in control group. The postoperative complications were hypotony maculopathy in 5 eyes, bleb leakage in one eye and cataract in 5 eyes. Conclusion: MMC could act effect of inhibition of fibroblast proliferatiosn after trabeculectomy and a higher success de on controlling IOP and functional bleb in long term evaluation. But some postoperative complications might occur.
出处
《伤残医学杂志》
2000年第1期13-16,共4页
Medical Journal of Trauma and Disability
