肿瘤细胞辐射敏感性相关蛋白研究进展

Study of Tumor Cells Radiosensitivity Associated Proteins

重点综述了Siah,HIF,NF-κB和DNA-PK蛋白与肿瘤细胞辐射敏感性关系的最新研究进展。总结了中国科学院重离子束辐射生物医学重点实验室近几年来在BRCA1等肿瘤细胞辐射敏感性相关蛋白方面的研究工作。简介了HLET C离子束治疗肿瘤的优点。展望了此实验室借助兰州重离子研究装置(HIRFL)提供的C离子束研究肿瘤细胞辐射敏感性相关蛋白的目标和方向。

The research progress of tumor cells radiosensitivity associated protein Siah, HIF, NF-kB and DNA-PK are summarized and reviewed. The recent works of our laboratory on tumor cells radiosensitivity associated proteins such as BRCA1 are demonstrated. In the present review, we focused on discussions about the advantages of heavy ion therapy and its possible application in the research of radiosensitivity as sociated proteins. At the end of this review, we highlighted the future trend and potential targets in the study of tumor cells radiosensitivity associated proteins.