精氨酸对全胃肠外营养大鼠肝脂肪变性的保护作用

Protective role of arginine in hepatic steatosis caused by total parenteral nutrition in rats

目的 :探讨精氨酸在全胃肠外营养 (total parenteral nutrition,TPN)引起的肝脂肪变性中的作用。 方法 :18只正常 Wistar大鼠随机分为三组 :A组 ,自由进食和水 ;B组 ,TPN ;C组 ,TPN+精氨酸。实验 7天后测体重、肝功能、门静脉胰岛素、胰高血糖素、肝重、肝内脂肪和肝组织学检查。 结果 :B组门静脉胰岛素与胰高血糖素比值(I/G)较 A组升高 (P<0 .0 5 ) ,C组门静脉 I/G值较 B组降低 (P<0 .0 5 )。 B组肝内脂肪较 A组增加 (P<0 .0 5 ) ,C组肝内脂肪较 B组减少 (P<0 .0 5 )。 结论 :精氨酸可以减少

Objectives:To investigate the effect of arginine for hepatic steatosis caused by total pareteral nutrition(TPN) in rats. Methods:Eighteen Wistar rats were randomly divided into three groups:Gourp A,chow ad libitum;Group B,TPN;Group C,TPN with arginine.At the seventh day,peripheral and portal venous blood samples were drawn for liver function tests and insulin and glucagon radioimmunoassay,and livers were resected for lipid content determination and histology. Results:Portal venous insulin/glucagon(I/G) ratio in group B was higher than that in group A( P <0.05),and the ratio in group C was lower than that in group B( P <0.05).Hepatic lipid content and hepatic steatosis in group B was significantly increased,and compared with group B the changes in group C was significantly decreased. Conclusions:Arginine may be protective for hepatic steatosis caused by total parenteral nutrition in rats.