TCT、阴道镜组织病理学及HPV检查在宫颈病变诊断中的意义

The Value of Thinprep Cytology Test （TCT） , Vaginoscope Histopathologic Examination and HPV-test in the Diagnosis of Cervical Disease

目的综合评价超薄液基细胞学（TCT）、阴道镜组织病理及人乳头状瘤病毒高危型（HR-HPV）检查在宫颈病变诊断中的应用价值.方法2007年1月~2010年12月期间,行 TCT 检查及健康查体者5836例,其中检出宫颈病变518例,对有宫颈病变患者进行阴道镜组织病理学检查,对 CINⅠ及以上的214例患者进行 HPV 检查.结果 TCT 与组织病理结果比较,符合率为86.3%.HPV 阳性率分别为 CINⅠ为19.4%（25/129）,CINⅡ52.8%（28/53）,CINⅢ及宫颈癌100%（32/32）,随着宫颈组织病理学级别增高,HPV 感染阳性率明显增高.结论 TCT、阴道镜组织病理学及 HPV 检查联合应用可以提高宫颈病变的检出率,有利于早预防、早诊断、早治疗,达到有效防治宫颈癌的目的.

Objective To evaluate the value of lhinprep cytology tent,vaginoseope Histopalhologic examination and HPV-test in llle diagnosis of cervical disease. Methods In January 2007 to FebruaD＇ 2010 period,5836 outpatients were given thinprep cytology Test （TCF} examination in ttospital. Five htmdred and eighteen cases of cervical lesions were flwther tmdelavent vaginoscope histopalhologie exam- ination. Two hundred and fl）nrleen ~＇anen of cervical intraepilhellal neoplasia and cancer were examined tbr HR-HPV by PCR. Results Among the 518 cases,the coincidence between the findings of TCT and pathology was 86.3%. The positive rate of HR-HPV of CIN [ , （;IN 11 , CIN m and cervical cancer was 19.4% （25/129） ,52.8% （28/53） and 100% { 32/32 ） respectively. The positive rate H R-HPV infection wan signifi- cantly raised with the increased level of cervical pathology. Obviously, HR-HPV examination in the diagnosis of cervical lesions in extremely important. Conclusion The combination of the above examination can increase the detection rate of lesions that can be beneficil Io early pre- vention,early diagnosis and early treatment,and ef｜ective prevention and treatment of cervical cancer.