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帕瑞昔布钠术前应用在乳腺肿块象限切除术中的效果观察

Effects of Parecoxib on Preoperative Analgesia in Regional Adenomammectomy
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摘要 目的评价非甾体类镇痛药帕瑞昔布钠在乳腺肿块象限切除术前的应用.方法采用前瞻性、双盲、随机和对照研究设计,择期行乳腺肿块象限切除术的 ASAⅠ-Ⅱ 级患者60例,按随机数字表法分为 C 组（对照组）和 P 组（帕瑞昔布钠组）,每组患者30例. P 组麻醉诱导前15min 静脉注射帕瑞昔布钠40mg,C 组在麻醉诱导前静脉注射同等容量的生理盐水.两组患者术中通过调节七氟烷吸入浓度维持 Narcotrend 指数在 D2~E1等级.记录七氟烷、芬太尼的用量,血流动力学指标、术中肢动及术后恢复情况.结果两组患者七氟烷用量没有差别（P 〉0.05）,芬太尼用量 P 组少于 C 组（P 〈0.05）.呼吸恢复时间、拔管时间 P 组均小于 C 组（P 〈0.05）.疼痛评分（VAS）、身体舒适度评分（ BCS）拔管后60min,120min,240min C 组高于 P 组（P 〈0.05）. Ramsay镇静评分（RSS）拔管后5min C 组高于 P 组（P 〈0.05）.结论帕瑞昔布钠术前15min 应用可减少乳腺肿块象限切除术中芬太尼的用量,缩短拔管时间,提高病人的舒适度.
作者 杨希营 王慧 隋艳 张岩
机构地区 潍坊医学院麻醉学系 潍坊医学院附属医院麻醉科 中国人民解放军第
出处 《潍坊医学院学报》 2012年第4期272-274,共3页 Acta Academiae Medicinae Weifang
关键词 帕瑞昔布钠 NARCOTREND 七氟烷 乳腺肿块
分类号 R614.2 [医药卫生—麻醉学]
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参考文献7

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潍坊医学院学报
2012年 第4期

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