急性重症胰腺炎与促炎细胞因子和炎性介质的关系

The interrelationship between acute severe pancreatitis and proinflammatory mediators and cytokines

急性重症胰腺炎是一种全身性炎症反应综合征 ,细胞因子和炎性介质在其发病过程中发挥重要的作用。本文综述了细胞因子中肿瘤坏死因子 - α、白细胞介素 - 1β、白细胞介素 - 6和白细胞介素 - 8,以及炎性介质中的磷脂酶A2 、前列腺素、血栓素、白三烯和血小板激活因子在急性重症胰腺炎发病过程中的作用 ,重点讨论了这些物质的来源和生理作用及其拮抗剂在胰腺炎治疗方面的潜力。

Acute severe pancreatitis is a kind of systemic inflammatory response syndrome in which cytokines and inflammatory mediators play pivotal role. The article reviewed the roles of tumor necrotizing factor α, interleukin 1β, interleukin 6, interleukin 8, prostaglandins, thromboxanes, leukotrienes and platelet activating factor in the pathogenesis of acute severe pancreatitis, the source, physiological functions and the potential indications of their antagonists were also discussed.