预处理对O_3衰老模型超氧化物歧化酶活性的影响

Protective effect of preconditioning with yunnan pollen tiench oral liquid on the activity of superoxide dismutase in mouse

为了确定预处理对小鼠 O3致衰老模型是否具有保护作用 ,本研究利用 SOD微量快速测定法 ,检测和分析了经云南花粉田七口服液 (Yun Nan Pollen Tienchi Oral L iquid,简称 YN- PTOL )预处理后小鼠全血和心肌中超氧化物歧化酶 (superoxide dismutase,SOD)的活性 ,结果显示 :预处理实验组 SOD活性明显高于空白对照组和阳性对照组 (P<0 .0 5 ) ,同时 ,空白对照组与阳性对照组之间无显著性差异。这表明 :YN- PTOL预处理能改善或提高 O3致老小鼠模型机体内 SOD活性 ,是一种有应用前景的延缓衰老的保健药物。

To investigate whether preconditioning have protective effect on aging model against oxidative damage from free radical, the activity of superoxide dismutase of plasma and myocardium was determined by SOD rapidly assay. The results showed that the experimental group had a higher SOD status than other groups (P<0.05). Meanwhile, the amount of SOD was no significant between the blank group and the positive group (P>0.05). It is evident that the precondintioning with YN-PTOL can increase or improve the activity of SOD in mouse.