正壬酸香草酰胺的制备与杀虫活性研究

Study on Synthesis and Insecticidal Activities of Nonivamide

[目的]探讨辣椒碱及其类似物正壬酸香草酰胺的杀虫活性。[方法]以香草醛和正壬酸为起始原料,经胺化还原反应、N-酰化反应制备了正壬酸香草酰胺,对其化学结构进行了EI-MS和1H NMR验证,并对辣椒碱和正壬酸香草酰胺进行了生物活性测定。[结果]辣椒碱和正壬香草酰胺对小菜蛾[Plutella xyllostella(Linnaeus)]3龄幼虫和蚕豆蚜(Aphis craccivora)3日龄若蚜均无明显的杀虫活性。[结论]为进一步研究辣椒碱的生物活性提供了理论依据。

[Objective] The aim was to explore the insecticidal activities of capsaicin and nonivamide.[Method] Synthetic nonivamide was prepared by reductive amination and N-acylation reaction with nonanoic acid and vanillin as starting materials,and the chemical structure of the target compound was confirmed by 1H NMR and EI-MS.The biological activities of synthetic nonivamide and capsaicin were tested.[Result] Both capsaicin and synthetic nonivamide had no obvious insecticidal activities against the 3rd instar larvae of Plutella xyllostella（Linnaeus） and 3-day-old nymphs of Aphis craccivora.[Conclusion] The research provides theoretical basis for further study on the insecticidal activities of capsaicin.