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ANCA相关性系统性小血管炎发病机制研究进展

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摘要 临床资料提示抗中性粒细胞胞浆抗体(ANCA)在系统性血管炎发生过程中有重要作用。各种体内外研究也提示了ANCA的致病性,ANCA可以激活已经致敏的中性粒细胞,产生活性氧类和水解酶类,破坏内皮细胞。除了ANCA的作用外,还涉及多种细胞因子、细胞免疫以及补体系统激活等方面。微生物因素触发系统性血管炎的作用也日益清楚,慢性携带金黄色葡萄球菌以及G-菌的感染都有利于AASV的发生。
出处 《长江大学学报(自科版)(下旬)》 CAS 2012年第9期70-73,共4页 Journal of Yangtze University
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