奥美拉唑与雷贝拉唑治疗难治性消化溃疡胃镜下近期疗效分析

Analysis of Short-Term Therapeutic Effect of Omeprazole and Rabeprazole on Refractory Digestive Ulcer under Gastroscope

目的分析对比奥美拉唑与雷贝拉唑两种质子泵抑制剂对难治性消化溃疡的近期疗效。方法对我院2008年至2011年间收治的难治性消化溃疡患者78例随机分为对照组和实验组各39例,对照组使用奥美拉唑三联疗法进行治疗,实验组使用雷贝拉唑三联疗法进行治疗,治疗两周后对两组患者行胃镜进行近期疗效的评价和对比。结果对照组总有效率为53.87%,实验组总有效率为87.18%,实验组总有效率显著高于对照组(P<0.05)。对照组Hp清除率94.87%,实验组Hp清除率97.43%,两组差异不显著(P>0.05)。两组均未出现严重不良反应。结论使用雷贝拉唑三联疗法能有效抑制胃酸分泌、清除幽门螺旋杆菌,促进溃疡面愈合,对难治性消化溃疡有较好的近期疗效。

Objective To analyze and compare the short-term therapeutic efficacy of omeprazole and rabeprazole on refractory digestive ulcer. Methods 78 patients with refractory ulcer during 2008 to 2011 in our hospital were randomly divided into control group and experimental group with 39 cases in each group. The control group was treated with omeprazole trigeminy therapy, while the experimental group was treated with rapeprazole therapy. Gatroscope was operated after treatment to evaluate and compare the short-term effectiveness. Results The experiment group had a significantly higher effective rate of 87.13% than the control group of 53.87% （P 〈0.05）. The clearance of Helicobacter pylori （Hp） of control group was 94.87% and the experiment group was 97.43%. The two groups had no significant difference （P 〉0.05）. None of the two groups was reported to have serious complications. Conclusions Rabeprazole-based triple therapy can effectively inhibit gastric acid secretion, clear Helicobacter pylori, and promote ulcer healing, which has preferable short-term therapeutic efficacy for refractory digestive ulcer.