伴复杂染色体改变的多发性骨髓瘤5例

Five cases of multiple myeloma with compalicated chromosomes abnormalities

目的:报告5例伴复杂染色体改变多发性骨髓瘤,结合文献复习,探讨染色体改变与临床特点及预后的关系。方法:对5例患者进行回顾性分析及相关文献复习。结果:5例患者病情进展迅速,临床试验药物均耐药,最终因器官衰竭而死亡。从出现复杂染色体改变到死亡的时间为1～11个月。结论:复杂染色体改变后病情迅速进展,化疗效果差,生存时间短。

Objective：To report five cases of multiple myeloma with compalicated chromosomes abnormalities,review the literatures,and explore the correlation between chromosomes abnormalities and clinical features and prognosis.Method：Five cases were reported and analyzed.Literatures were reviewed.Result：All the patients progressed rapidly and were resisted to chemotherapeutic drugs,including Velcade,Lenalidomide.Finally five patients died during 1 to 11 months after diagnosis.Conclusion：Rapid progress,bad treatment effect,and short survival time were observed in patients with compalicated chromosomes abnormalities.