镍铬合金烤瓷修复体拆除前后患者血清镍铬含量的检测与评估

Detection and assessment of serum nickel and chromium levels in patients before and after the removal of the nickel-chromium alloy porcelain-fused-to-metal restoration

背景:目前关于镍铬合金烤瓷修复体是否会对人体造成系统性影响的研究尚较少报道。目的:通过对镍铬合金烤瓷修复体拆除前后患者血清中镍铬元素含量的测定,对其临床应用安全性进行科学评估。方法:选取因怀疑镍铬烤瓷修复体的镍、铬元素对全身有影响,而要求拆除原修复体的患者69例,在修复体拆除前、拆后1个月,分别运用石墨炉原子吸收光谱法对患者血清中镍、铬含量进行检测,并按年龄、性别、修复体数目、修复体戴入时间以及修复体有无金属暴露等因素进行分组分析。结果与结论:69例患者在镍铬烤瓷修复体拆除前后所测的血清镍、铬含量结果差异无显著性意义(P>0.05),而且患者的血清镍、铬含量与年龄、性别、修复体的数量、修复时间以及有无金属暴露等均无明显的相关性(P>0.05)。提示镍铬合金烤瓷修复体所释放的镍、铬离子量微小,不足以对人体血清中的镍、铬含量造成影响。

BACKGROUND：Currently,there are few reports on whether the nickel-chromium alloy porcelain-fused-to-metal（PFM） restoration has a systematic effect on the human body.OBJECTIVE：To investigate the clinical security of the nickel-chromium alloy PFM,according to the assessment of the serum levels of nickel and chromium before and after the removal of the restoration.METHODS：Sixty-nine patients were selected for the study,who suspected that nickel-chromium alloy PFM could affect their health and therefore came to hospital to ask for removal of the crown.The serum levels of nickel and chromium in these 69 patients were detected before and 1 month after the removal of the nickel-chromium alloy PFM restorations.In addition,the serum levels of nickel and chromium in these patients were analyzed according to their age,gender,the number and duration of PFM restorations,and whether the metal was exposed or not in restoration.RESULTS AND CONCLUSION：There were no statistical differences between the serum levels of nickel and chromium in patients before and after the removal of the nickel-chromium alloy PFM restoration（P 〉 0.05）.In addition,the serum levels of nickel and chromium in patients had nothing to do with gender,age,the number and duration of PFM restorations,and whether the metal was exposed or not in restoration（P 〉 0.05）.The amount of nickel and chromium released from nickel-chromium alloy PFM is small,which cannot affect the serum levels of nickel and chromium in the human body.