红霉素微球的制备及质量分析

Preparation and Quality Analysis of Erythromycin Microsphere

目的：优化红霉素微球的制备工艺.方法：以聚乳酸为载体材料,采用乳化溶剂-挥发法制备红霉素微球,并以微球的包封率和载药量为考察指标,进行了L9（34）的正交试验.结论：优选后的制备方法稳定可行,适合于红霉素微球的制备,从而制备工艺得以改进.

Objective：To optimize the preparation technology of erythromycin microspheres. Methods：Poly lactic acid as the carrier material,adopt Emulsion solvent--volatile method to preparation erythromycin microspheres, With small ball bag sealing rate and the drug for complete index use L2 （34） of orthogonal test. Conclusion：The optimal extraction process is stable and feasible and suitable for, thus preparation technology to improve.