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High incidence of nasopharyngeal cancer: similarity for 60% of mitochondrial DNA signatures between the Bidayuhs of Borneo and the Bai-yue of Southern China

High incidence of nasopharyngeal cancer: similarity for 60% of mitochondrial DNA signatures between the Bidayuhs of Borneo and the Bai-yue of Southern China
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摘要 Populations in Southern China (Bai-yue) and Borneo (Bidayuh) with high incidence of nasopharyngeal cancer (NPC) share similar mitochondrial DNA signatures, supporting the hypothesis that these two populations may share the same genetic predisposition for NPC, which may have first appeared in a common ancestral reference population before the sea levels rose after the last ice age. Populations in Southern China （Bai-yue） and Borneo （Bidayuh） with high incidence of nasopharyngeal cancer （NPC） share similar mitochondrial DNA signatures, supporting the hypothesis that these two populations may share the same genetic predisposition for NPC, which may have first appeared in a common ancestral reference population before the sea levels rose after the last ice age.
作者 Joseph Wee Tam Cam Ha Susan Loong Chao-Nan Qian
机构地区 Department of Radiation Oncology Division of Clinical Trials&Epidemiological Sciences Duke-NUS Graduate Medical School State Key Laboratory of Oncology in South China Van Andel Research Institute
出处 《Chinese Journal of Cancer》 SCIE CAS CSCD 2012年第9期455-456,共2页
关键词 线粒体DNA 中国南方 相似性 婆罗洲 发病率 鼻咽癌 签名 遗传易感性 Nasopharyngeal cancer, incidence, DNA signatures
分类号 R739.63 [医药卫生—肿瘤]
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Chinese Journal of Cancer
2012年 第9期

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