血纤维蛋白原 胱抑素 C在急诊胸痛的临床意义

Clinical value of plasma fibrinogen and serum cystatin C in acute chest pain

目的探讨急诊胸痛患者血浆纤维蛋白原（fibrinogen，Fg）、血清胱抑素C（cystatin C，Cys C）水平及其对急诊胸痛患者诊断、预后的意义。方法检测对象为2010—01—2011—01我院急诊科接诊的急诊胸痛患者484例，其中不稳定型心绞痛（unstable angina pectoris，UAP）组253例，急性心肌梗死（acute myocardial infarction，AMI）组126例；非急性冠脉综合征（acute coronary syndrome，ACS）105例为对照组。用Clauss法测定血浆Fg浓度，免疫比浊法测定血清CysC浓度。结果UAP组和AMI组的血浆Fg均高于对照组（P〈0．05），UAP组血清Cys C较对照组高（P〈0．05），但AMI组血清Cys C与对照组比较差异无统计学意义（P〉0．05）；而UAP组与AMI组血清Cys C比较差异有统计学意义（P〈0．05）。结论血Fg、Cys C水平的升高可能对急诊胸痛患者的诊断有一定的价值，有助于判别ACS的存在和预后。

Objective To study the diagnostic and prognostic values of plasma fibrinogen（Fg） and serum cystatin C （ Cys C） of patients with acute chest pain. Methods We collected 484 cases with acute chest pain from January 2010 to January 2011. Unstable angina pectoris （UAP） group had 253 cases, acute myocardial infarction （AMI） group had 126 cases, and there were 105 cases with acute coronary syndrome （ACS） as control group. The Clauss method was used to detect the plasma Fg level, and the serum Cys C was measured by immunoturbidimetry. Results The level of plasma Fg and serum Cys C in UAP group and the level of plasma Fg in AMI group were higher than those in control group （P 〈 O. 05 ）, but there was no difference in the level of Cys C between AMI group and control group （P 〉 0. 05）. And there was statistical difference in the level of blood Fg and Cys C between UAP group and AMI group（P 〈 0.05）. Conclusion The level of blood Fg and Cys C can help the diagnosis and prognosis of ACS.