槲皮素治疗HPV阳性的ASCUS患者40例

Clinical efficacy of Quercetin in The Treatment For 40 Cases of HPV-positive ASCUS patients

目的探讨槲皮素治疗HPV阳性的宫颈鳞状上皮不典型增生(ASCUS)患者的临床疗效。方法将80例HPV阳性的ASCUS患者随机分为两组:治疗组40例,用中药槲皮素宫颈局部上药,1周2次,4周为1个疗程,连续治疗2个疗程;对照组40例,阴道常规清洁、每周2次、连续2月;两组患者均在治疗后6个月随访,复查TCT和HPV。结果治疗组TCT正常患者33例,总有效率为82.5%;对照组TCT正常患者17例,总有效率为42.5%;比较差异有统计学意义(P<0.01)。HPV检测,治疗组转阴31例,转阴率为77.5%,对照组转阴12例,转阴率为30.0%;比较差异有统计学意义(P<0.01)。结论中药槲皮素对HPV阳性的ASCUS患者有较明显的疗效。

Objective To analyze clinical effect of Quercetin in the treatmrut of HPV - positive ASCUS patients. Methods 80 cases of HPV - positive ASCUS patients were randomly assigned into two groups： Treatment group （ n = 40） , traditional Chinese medicine drug quercetin was used on the cervical part, two times a week, four weeks for a course of treatment, continuous treatment of the two courses; Control group （ u = 40）, to patients with conventional cleaning the va- gina twice a week for two months. All patients were followed up after six months, reviewed of TCT and HPV. Results There were 33 cases in treatment group being normal by the TCT screening, the effective rate was 82.5 % ; But the control group only had 17 normal patients with a effective rate of 42.54 %. There was statistically significant difference between the two groups （ P 〈 0. 01 ）. We detected HPV - DNA, the negative cases in the treatment group and control group were 31 and 12 cases; The negative conversion rate in two groups were 77.5 % and 30 % respective; There was statistically significant difference between the two groups （ P 〈 0. 01 ）. Conclusions Quercetin has a more significant effect on HPV -positive ASCUS patients.