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水通道蛋白1在哺乳动物体内的分布及功能 被引量：2

Distribution and function of aquaporin 1 in the mammalian body
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摘要 水通道蛋白1(aquaporins1,AQP1)是参与水分子跨膜转运的重要膜通道蛋白家族成员之一,广泛分布于各组织中,在机体物质代谢和水平衡中起着重要的作用。本文就AQP1在哺乳动物各组织中的表达和分布及其参与脑脊液的产生、细胞生物学特性的调节和感觉传导等方面相关功能的研究现况和进展作一综述。 Aquaporinl （AQP1）, one of the most important water-transport membrane channel protein family members, is extensively distributed in various tissue and contributes to the maintenance of metabolism and water balance. In this review, we summarized the localization and expression of AQP1 in different tissues in the mammalian body and recent progress of its role in the cerebrospinal fluid production, cellular biological characteristic modulation and sensory transduction.
作者 蔡倩倩 高俊英 谭美芸 肖明
机构地区 南京医科大学人体解剖学系
出处 《解剖科学进展》 CAS 2012年第5期469-472,共4页 Progress of Anatomical Sciences
基金 国家自然科学基金资助项目(Ky1010121091111127)
关键词 水通道蛋白1 哺乳动物 动物体内 细胞生物学特性 机体物质代谢 家族成员 跨膜转运 感觉传导
分类号 Q469 [生物学—生理学]
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参考文献30

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同被引文献23

  • 1梁棋,徐三荣,刘伟,邓丽贤,孙大裕.水通道蛋白-1在肝硬化腹水大鼠腹膜上的表达[J].中华医学杂志,2005,85(15):1027-1030. 被引量：5
  • 2朱平,宋雁南,张亚坤,吴振铎,金连弘,李学均,刘爱莲,迟凤琴.人胚胎肾脏发育的超微结构研究　Ⅱ．肾小管的发育[J].哈尔滨医科大学学报,1994,28(5):382-384. 被引量：3
  • 3Liu H,Song D,Lee SS. Role of heme oxygenase-carbon monoxide pathwayin pathogenesis of cirrhotic cardiomyopathy in the rat. Am J Physiol Cas-trointest Liver Physiol,2001,280:G68-G74.
  • 4Hachez C,Chaumont F. Aquaporins : a family of highly regulated multi-functional channels. Adv Exp Med Biol ,2010,679 : 1 -17.
  • 5Ishibashi K,Hara S, Kondo S. Aquaporin water channels in mammals.Clin Exp Nephrol,2009,13:107-117.
  • 6Matsuzaki T,Hata H,Ozawa H,et al. Immunohistochemical localization ofthe aquaporins AQP1,AQP3,AQP4 and AQP5 in the mouse respiratorysystem. Acta Histochem Cytochem,2009,42: 159-169.
  • 7Ma T, Yang B,Gillespie A,et al. Severely impaired urinary concentratingability in transgenic mice lacking aquaporin-1 water channels. BiolChem,1998,273:42964299.
  • 8Pallone TL, Edwards A, Ma T, et al. Requirement of aquaporin-1 forNaCl-driven water transport across descending vasa recta. Clin Invest,2000,1115:215-222.
  • 9Xu PX,Zheng W,Huang L,et al.Six1 is required for the early organogenesis of mammalian kidney.Development,2003,130(14):3085-3094.
  • 10Kobayashi E,Hishikawa S,Teratani T,et al.The pig as a model for translational research:overview of porcine animal models at Jichi Medical University.Transplant Res,2012,16(1):8.

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解剖科学进展
2012年 第5期

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