脑卒中与线粒体途径凋亡相关因子的研究进展

Progress of apoptosis-related factors in mitochondrial pathway of stroke

脑卒中导致的脑神经元凋亡过程中,存在着大量正性和负性的可调控相关因子,这些可调控因子可作为治疗脑卒中的潜在靶点。研究表明,脑卒中神经元细胞凋亡主要是由Caspase的级联反应所调控,细胞凋亡的主要途径之一是线粒体凋亡通路,Bcl-2家族蛋白主要调节Caspase的激活。线粒体释放的与凋亡相关的因子也对Caspase的激活有调节作用,而这些与凋亡相关的因子又受Bcl-2蛋白所调节。对脑卒中神经元凋亡过程中线粒体途径调控相关因子的研究是寻找和开发治疗脑卒中药物的重要理论基础。

There are many positive and negative regulatory factors during neuronal apoptosis caused by stroke, these regulatory factors are potential targets for treatment of stroke. Studies have shown that stroke neuronal apoptosis are regulated by caspase cascade, one of the main ways of apoptosis is the mitochondrial apoptosis pathway, the Bcl-2 family proteins regulate the activation of caspase, however, apoptosis-related factors of mitochondrial also regulates the activation of caspase, and also apoptosis-related factors of mitochondrial are regulated by the Bcl-2 proteins. Study of mitochondrial pathway regulatory factors of stroke neuronal apoptosis will provide an important theoretical basis for finding treatment drug of stroke.