54株白假丝酵母菌感染及药敏分析

Analysis of 54 cases infected with Candida albicans strains and drug resistance

目的了解海南省人民医院白假丝酵母菌的感染情况,分析该医院临床分离的白假丝酵母菌对抗常见真菌药物氟胞嘧啶、两性霉素、氟康唑、伊曲康唑、伏立康唑的体外敏感性,为控制该菌感染和指导临床合理使用抗真菌药物提供参考。方法收集、分离、鉴定临床送检标本,用微量稀释法测定临床分离白假丝酵母菌对5种抗真菌药物的敏感性,结果用各个药物的最低抑菌浓度(MIC)表示,并对这些白假丝酵母菌感染患者的病历进行统计分析。结果共检出54株白假丝酵母菌,其对氟胞嘧啶、两性霉素、氟康唑、伊曲康唑、伏立康唑的敏感性分别为85.2%,98.1%,33.3%,22.2%,31.5%。结论白假丝酵母菌对两性霉素敏感性最高。

objective To understand infectious situation of Candida albicans in Hainan Provincial People＇s Hospital and analyze the in vitro susceptibility of clinical isolates to antifungal drugs. Methods Clinical samples were collected and Candida albicans strains were isolated and identified. The sensitivity rates of the Candida albieans strains to 5 antifungal drugs were tested by microbroth method. Each drug＇s results were recorded as minimum inhibitory concentration（MIC）. These patients ＇medical records of Candida albican~ infection were collected for statistical analysis. Flesotts Totally 54 strains were isolated, the sensitivity rates of Candida albicans strains to fluorocytosine,amphotericin,fluconazole,itraconazole and voriconazole were 85.2% ,98.1% ,33.3% ,22.2% and 31.5% respectively. Conclusion Candida albicans is highly sensitive to amphoteriein among the five antifungal drugs.