川芎嗪对慢性肺心病急性期疗效及血液流变学指标的影响

Effects of Ligustrazine on hemorheology of chronic pulmonary heart disease patients at acute phase

目的比较两个品种的川芎嗪注射剂对慢性肺心病急性期患者疗效,成本一效果以及血液流变学影响。方法选择本院2008年2月~2012年2月住院的慢性肺心病急性期患者90例,随机分为治疗组和对照组各45例,两组按常规对症治疗,并分别加用盐酸川芎嗪注射液和注射用盐酸川芎嗪,观察两组疗效、药物成本及血液流变学。结果总有效率治疗组88.9%、对照组91.1%,两组比较并无统计学意义（P〉0.05）。而药费平均每人治疗组76.30元、对照组831.46元,两组间差异有统计学意义（P〈0.05）。结论川芎嗪对慢性肺心病急性期疗效较好,且对血液流变学均有改善,而盐酸川芎嗪注射液成本低,值得临床推广。

Objective To compare the effects of two different forms of ligustrazine on hemorheology of chronic pulmonary heart disease patients at acute phase and analyze the cost-effectiveness. Methods Ninety patients with ehronic pulmonary heart disease hospitalized in Haigang Branch Hospital of Haikou Municipal People＇ s Hospital during Feb. 2008-Feb. 2012 were selected and randomly divided into treatment group and control group each consisted of 45 patients. Both groups accepted routine treatment,and were injeeted with tetramethylpyrazine hydroohloride and hydrochloric acid containing ligustrazine,respectively. Then the hemorheology indices,efficacy in the two groups were anlayzed. Results The total effective rate of treatment group was 88.9% and 91.1% in theeonlrol group. There was no statistical signifieant differences between the two groups. The average costs in the treatment group and control group were 76.30 and 831.46 RMB yuan per case,showing statistically significant differences （P〈0.05）. Conclusion The effect of ligustrazine on patients with acute chronic cor pulmonale is good with light side effects. The cost of injection with hydrochloric acid ligustrazine is low and it is worthy of clinical application.