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胰岛素与癌症 被引量：3

Relationship between the insulin and cancer
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摘要 一系列流行病学调查资料提示,2型糖尿病使多种癌症的发病风险增加;同时2型糖尿病的治疗可能会改变这种相对危险度,例如二甲双胍治疗的患者中肿瘤的发生风险减小,
作者 付建芳 姬秋和
机构地区 第四军医大学西京医院内分泌代谢科
出处 《药品评价》 CAS 2012年第22期39-43,共5页 Drug Evaluation
关键词 胰岛素 癌症 高胰岛素血症 胰岛素类似物
分类号 R587.1 [医药卫生—内分泌]
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参考文献45

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  • 2Mynarcik DC, Williams PF, Schaffer L, et al. Identification of common ligand binding determinants of the insulin and insulin-like growth factor I receptors. Insights into mechanisms ofligand binding[J]. J Biol Chem, 1997, 272(30): 18650-18655.
  • 3Slicker LJ, Brooke GS, DiMarehi RD, et al. Modifications in the BI0 and B26-30 regions of the B chain of human insulin alter affinity fbr the human IGF-I receptor more than for the insulin receptor[J]. Diabetologia, 1997, 40(Suppl 2): S54-S61.
  • 4Milazzo G, Sciacca L, Papa V, et al. ASPBI0 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-1 receptor[J]. Mol Carcinog, 1997, 18(1 ): 19-25.
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  • 6Yakar S, Nunez NP, Pennisi P, et al. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones[J]. Endocrinology, 2006, 147(12): 5826-5834.
  • 7Rechler MM, Nissley SP. The nature and regulation of the receptors for insulin-like growth factors[J]. Annu Rev Physiol, 1985, 47: 425-442.
  • 8Wasada T, Kawahara R, Iwamoto Y, et al. Lack of evidence for bromocriptine effect on glucose tolerance, insulin resistance, and body fat stores in obese type 2 diabetic patients[J]. Diabetes Care, 2000, 23(7): 1039-1040.
  • 9Ma J, Li H, Giovannueci E, et al. Precliagnostic My-mass index, plasma C-pepfide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis[J]. Lancet Oncol, 2008, 9(11): 1039-1047.
  • 10Jenab M, Riboli E, Cleveland RJ, et al. Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition[J]. lnt J Cancer, 2007, 121(2): 368-376.

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药品评价
2012年 第22期

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