喹硫平抗焦虑的增效作用探析

Quetiapine Augmentation in the Treatment of Anxiety

目的探讨喹硫平对艾司西酞普兰治疗广泛性焦虑障碍的增效作用及安全性。方法将60例广泛性焦虑障碍患者随机分为艾司西酞普兰组和艾司西酞普兰合并喹硫平组,治疗6周。给予治疗前,治疗1,2,6周,分别用Hamilton焦虑量表(HAMA)及治疗中出现的症状量表(TESS)评定疗效及不良反应。结果合用喹硫平组疗效显著优于艾司单用西酞普兰组。合并组治疗各周HAMA评分下降比单用组更为显著。两组TESS评分无显著差异。结论合用喹硫平对于广泛性焦虑障碍的治疗有明显的增效作用,且起效更迅速。

Objective To explore the effect of quetiapine augmentation with escitalopram in the treatment of generalized anxiety disorder.Method 60 cases with generalized anxiety disorder were randomly assigned to escitalopram group and escitalopram with quetiapine group for 6 weeks.Use Hamilton anxiety scale （HAMA） and treatment emergent symptom （TESS） to assess the therapeutic effect and the side effect respectively at baseline and week 1, 2 and 6.Result The escitalopram with quetiapinegroup showed higher efficacy and more HAMA score reduction than escitalopram group. There were no significant differences in TESS between two groups. Cone I us i on Quetiapine with escitalopram can augment the efficacy in the treatment of generalized anxiety disorder.