连栀矾溶液加锡类散保留灌肠治疗慢性溃疡性直肠炎疗效观察

Retention Enema with Lianzhifan Solution plus Xilei San in the Treatment of Chronic Ulcerative Rectitis

为探讨连栀矾溶液加锡类散保留灌肠治疗慢性溃疡性直肠炎的临床疗效，选择2009年5月至2010年3月我院肛肠科慢性溃疡性直肠炎患者120例，随机分为三组，各40例，一组采用连栀矾溶液加锡类散保留灌肠治疗（治疗组），一组单纯采用锡类散保留灌肠治疗（对照A组），一组采用庆大霉素、甲硝唑注射液保留灌肠治疗（对照B组），对比分析三组疗效。结果显示，治疗组、对照A组、对照B组治愈率分别为77．5％、45．0％和47．5％；总有效率分别为97．5％、77．5％和70．0％。治疗组治愈率和总有效率明显高于对照A组和对照B组，P〈0．05；对照A组与对照B组治愈率和总有效率差异无统计学意义，P〉0．05。治疗后频繁便意感、黏液脓血便及肠镜检查积分均显著下降，P〈0．05；与对照A组和对照B组相比，治疗组各项指标积分降低更明显，P〈0．05。结果表明，连栀矾溶液加锡类散保留灌肠治疗慢性溃疡性直肠炎操作简单，疗效显著。

This study was to investigate the curative effect of retention enema with Lianzhifan solution plus Xilei San for treating chronic ulcerative rectitis. The 120 cases with this disease admitted in author＇s dept. （2009-05 to 2010-03） were randomly divided into three groups,40 cases for each.treatment group was sub- jected to the combination retention enema, control group A（i. e group A） to Xilei San（Chinese drug formu- la） alone,control group B（i. e group B） to gentamycin plus metronidazole for retention enema;then com- pared and analysed the curative effects of the 3 groups. As results,the curative rate of treatment group, group A,and B was 77.5%,45.0% and 47.5%the total effective rate of above 3 groups was 97.5%,77. 5 % and 70.0 %,respectively;the curative rate and total effective rate of treatment group were significantly higher than that of group A and B （P 〈0.05）,while between group A and B there was no statistical differences （ P 〉0.05） ;after treatment the frequent defecation sensation, muco-pus and blood stool, and en- teroscopy were scored as distinct decline rating points（ P 〈0.05） ,but compared with group A and B treat- ment group apperaed more significantly decline（ P 〈0.05）. Results show that retention enema with Li- anzhifan solution plus Xilei San in the treatment of chronic ulcerative rectitis is of simple manipulation and significant curative effect.