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肌氨酸及其在前列腺癌诊治中的作用 被引量：3

The Role of Sarcosine in the Diagnosis and Treatment for Prostate Cancer
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摘要 有研究提示尿液肌氨酸水平似乎可以成为诊断恶性侵袭性前列腺癌的新型分子标志物,其比血清前列腺特异性抗原更具特异性和灵敏性,但这一结论尚存在争议。全文结合了两种不同的研究文献,对肌氨酸及其在前列腺癌诊治中的作用作一综述。
作者 徐朝江 丁雪鹰 王卓
机构地区 嘉兴第二医院 第二军医大学附属长海医院
出处 《肿瘤学杂志》 CAS 2012年第8期579-583,共5页 Journal of Chinese Oncology
关键词 肌氨酸 前列腺肿瘤 分子标志物 尿液 前列腺特异性抗原
分类号 R737.25 [医药卫生—肿瘤]
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参考文献17

  • 1Allen RH,Stabler SP,Lindenbaum J. Serum betaine,N,N- dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism [J]. Metabolism, 1993,42(11):1448-1460.
  • 2Sreekumar A,Poisson LM,Rajeniran TM,et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression [J]. Nature,2009,457 (7231): 910-914.
  • 3Couzin J. A urine test for prostate cancer? [J/OL]. Science now. http://news.seieneemag.org/sciencenow/2009/02/11 - 01.html, 2009-02-11.
  • 4Lucarelli G,Larocca A, Fanelli M,et al. Serum sarcosine increases the accuracy of prostate cancer detection in low range PSA [J]. Eur Urol (Suppl), 2011,10(2):205,s633.
  • 5Jentzmik F,Stephan C ,Miller K, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours [J]. Eur Urol,2010,58(1):12-18.
  • 6Struys EA,Heijboer AC,van Moorselaar J,et al. Serum sarcosine is not a marker for prostate cancer [J]. Ann Clin Biochem, 2010,47(Pt 3):252.
  • 7Abate-Shen C,Shen MM. Diagnostics: the prostate-cancer metabolome [J]. Nature,2009,457(7231): 799-800.
  • 8Couzin J. Metabolite in urine may point to high-risk prostate cancer [J]. Science,2009,323(5916): 865.
  • 9Schalken JA. Is urinary sarcosine useful to identify patients with significant prostate cancer? The trials and tribulations of biomarker development [J]. Eur Urol, 2010,58(1): 19-20.
  • 10Colleselli D, Stenzl A, Schwentner C. Re:Florian Jentzmik,Carsten Stephan,Kurt Miller,et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours [J]. Eur Urol,2010,58(5):e51.

同被引文献48

  • 1张青云,徐建军,王雅明.人神经元特异性烯醇化酶在肿瘤细胞系中的表达检测及意义[J].中华检验医学杂志,2005,28(7):728-731. 被引量：12
  • 2吴澄宇,那彦群,JorgeL.Yao,P.AnthonydiSant'Agnese,黄教悌.前列腺癌的神经内分泌分化[J].中华病理学杂志,2006,35(9):565-567. 被引量：7
  • 3Jemal A,Bray F,Center MM. Global cancer statistics[J].CA-A Cancer Journal for Clinicians,2011,(02):69-90.
  • 4Siegel R,DeSantis C,Virgo K. Cancer treatment and survivorship statistics,2012[J].CA-A Cancer Journal for Clinicians,2012,(04):220-241.
  • 5Macfarlane RJ,Chi KN. Research in castration-resistant prostate cancer:what does the future hold[J].Curr Oncol,2010,(Suppl 2):80-86.
  • 6Scher HI,Halabi S,Tannock I. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone:recommendations of the prostate cancer clinical trials working group[J].Journal of Clinical Oncology,2008,(07):1148-1159.doi:10.1200/JCO.2007.12.4487.
  • 7Tavassolia FA,Devilee P. World Health Organization classification of tumours Pathology & genetics tumours of the breast and female genital organs[M].Lyon.:IARC Press,2003.32-40.
  • 8Huang J,Yao JL,di Sant'Agnese PA. Immunohistochemical characterization of neuroendocrine cells in prostate cancer[J].PROSTATE,2006,(13):1125-1135.
  • 9da Silva HB,Amaral EP,Nolasco EL. Dissecting major signaling pathways throughout the development of prostate cancer[J].Prostate Cancer,2013.920612.
  • 10Sarwar M,Sandberg S,Abrahamsson PA. Protein kinase A (PKA) pathway is functionally linked to androgen receptor(AR) in the progression of prostate cancer[J].Urologic Oncology,2013.

引证文献3

二级引证文献6

肿瘤学杂志
2012年 第8期

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