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GST-π、NQO1在子宫内膜癌组织中的表达及意义 被引量：1

EXPRESSION OF GST-πAND NQO1 IN ENDOMETRIAL CANCER AND THEIR CLINICAL SIGNIFICANCE
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摘要 目的探讨谷胱甘肽S-转移酶(glutathione-S-transferase,GST-π)、醌氧化还原酶1(quinoneoxidoreductasel,NQO1)在子宫内膜癌中的表达和意义。方法采用免疫组织化学方法检测32例子宫内膜腺癌组织和40例正常子宫内膜组织GST-π、NQO1的表达情况。结果 GST-π和NQO1在子宫内膜癌组织中的表达明显高于正常子宫内膜组织,差异有统计学意义(P<0.05)。NQO1在Ⅲ期子宫内膜癌中的表达明显高于Ⅰ期,差异有统计学意义(P<0.05)。结论 GST-π、NQO1与子宫内膜癌的发生密切相关;检测NQO1可作为判断晚期子宫内膜癌预后的指标。 Objective To investigate the expression of glutathione - S - transferase （ GST - π） and quinone oxidoreductasel （NQO1） in endometrial cancer tissues and their clinical significance. / Methods The immunohistochemical method was used to determine the expression of GST -π and NQO1 in 32 endometrial cancer tissues and 40 normal uterine endometrial tissue. Results The expression of GST- π and NQO1 in endometrial cancer tissues were significantly higher than those in normal uterine endometrial tissue. NQO1 expression in stage III endometrial cancer was significantly higher than that of stage I （P = 0.002）. Conclusion Expression of GST - π and NQO1 is closely related to the endometrial cancer. And the expression of NQO1 could be a good prognostic factor of endometrial cancer.
作者 石莉 高秀泽 李利
机构地区 河北省保定恒兴中西医结合医院妇产科 河北省保定恒兴中西医结合医院麻醉科 河北医科大学第四医院妇产科
出处 《河北医科大学学报》 CAS 2012年第9期1015-1017,共3页 Journal of Hebei Medical University
基金 河北省自然科学基金资助项目(C2006000857)
关键词 子宫内膜肿瘤 谷胱甘肽转移酶 氧化还原酶类 endometrial neoplasms glutathione transferase oxidoreductases
分类号 R737.33 [医药卫生—肿瘤]
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参考文献8

  • 1KELLERT IM, BOTTERWECK AA, HUVENEERS JA, et al. Trends in incidence of and mortality from uterine and ovarian cancer in Mid and South Limburg,The Netherlands, 1986- 2003 [ J]. Eur J Cancer Prey,2009,18 ( 1 ) :85 - 89.
  • 2CAVALIERI E, CHAKRAVARTI D, GUTTENPLAN J, et al Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention [ J ]. Biochim Biophys Acta,2006,1766 ( 1 ) :63 - 78.
  • 3WARHOLM M, GUTHENBERG C, MANNERVK B, et al. Purification of anew glutathione s - transferase ( transferase ) from human liver having high activity with benzo (a) pyrene - 4,5 - oxide [ J ]. Biochem Biophys Res Commun, 1998,98 ( 5 ) : 512.
  • 4MCGLYNN KA, ROSUOLD EA, LUSTBADER ED, et al. Susceptibility tohepatocellular carcinoma is associated with genetic variation in theenzymatie detoxifieation of aflatoxin B1 [J]. Proc Natl Acad Sci USA,2005,92(21 ) :2389.
  • 5DINKOVA- KOSTOVA AT, TALALAY P. Persuasive evidence that quinine reductase type 1 (DT diaphorase)protects ceils against the toxicity ofelectrophiles and reactive forms of oxygen [ J ]. Free Radic Bio Med,2007,29(3/4) :231 -240.
  • 6JAISWAL AK, MCBRIDE OW, ADESNIK M, et al. Human dioxin - induciblecytosolic NAD ( P ) H : menadione oxidoreductase, cDNA sequence andlocalization of gene to chromosome 16 [ J ]. J Biol Chem, 1988,263 ( 27 ) : 13572 - 13578.
  • 7KUEHL BL, PATERSON JW, PEACOCK JW. Presence of a heterozygous substitution and its relationship to DT - diaphorase activity [ J ]. Br J Cancer, 1995,72 (3) : 555 - 561.
  • 8代恩勇,卢振霞,史洁萍,于雅琴,张静.NQO1基因多态性与大肠癌遗传易感性[J].中国肿瘤临床,2004,31(2):89-91. 被引量：11

二级参考文献11

  • 1[1]Jaiswal AK, McBride OW, Adesnik M, et al. Human dioxininducible cytosolic NAD(P)H: menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16[J]. J Biol Chem, 1988, 263(27): 13572～13578
  • 2[2]Tvaver RD, Horikosh T, Danenberg KD, et al. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity [J]. Cancer Res, 1992, 52(4): 797～802
  • 3[3]Monks TJ, Hanzlik RP, Cohen GM, et al. Quinone chemistry and toxicity[J]. Toxicol Appl Pharmacol, 1992, 112(1): 2～16
  • 4[4]Siegel D, Anwar A, Winski SL, et al. Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD (P)H:quinone oxidoreductase 1 [J]. Mol Pharmacol, 2001, 59(2):263 ～268
  • 5[5]Kuehl BL, Paterson JW, Peacock JW, et al. Presence of a heterozygous substitution and its relationship to DT-diaphorase activity[J]. Br J Cancer, 1995, 72(3): 555～561
  • 6[6]Kelsey KT, Ross D, Traver RD, et al. Ethnic variation in the prevalence of a common NAD (P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy[J]. BrJ Cancer, 1997, 76(7): 852～854
  • 7[7]Gaedigk A, Tyndale RF, Jurima-Romet M, et al. NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations[J]. Pharmacogenetics, 1998, 8(4): 305～313
  • 8[8]Long DJ 2nd, Waikel RL, Wang XJ, et al. NAD (P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to,12-dimethyl-benz [a]-anthracene induced carcinogenesis in mouse skin[J]. J Natl Cancer Inst, 2001, 93(15): 1166～1170
  • 9[9]Asher G, Lotem J, Cohen B, et al. Regulation of p53 stability and p53-dependent apoptosis by NADH quinoneoxidoreductase 1[J]. Proc Natl Acad Sci USA, 2001, 98(3): 1188～1193
  • 10[10]Asher G, Lotem J, Kama R, et al. NQO1 stabilizes p53through a distinct pathway[J]. Natl Acad Sci USA, 2002, 99(5): 3099～3104

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河北医科大学学报
2012年 第9期

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