417例孕产妇孕期血碱性磷酸酶变化及其意义

Clinical implications of serum alkaline phosphatase in 417 pregnant women

目的探讨正常妊娠孕妇空腹血清碱性磷酸酶（AKP）在不同孕周的变化情况，及胎儿畸形孕妇血清AKP水平变化及其意义。方法检测300例不同孕周正常妊娠孕妇及117例胎儿畸形孕妇血清AKP水平并进行比较分析。结果正常妊娠孕妇血清AKP随妊娠的进展呈逐渐升高趋势，足月时达最高峰，产后明显下降；妊娠〈13周与妊娠21～24周胎儿心脏畸形孕妇与同期正常妊娠孕妇比较，血清AKP值明显降低；妊娠17—21周胎儿其他畸形孕妇比正常孕妇血清AKP值降低，差异均有统计学意义。结论孕妇血清中AKP随孕周增加而逐渐升高。血清AKP可作为孕期胎盘和胎儿状况的监测指标。

Objective To characterize variations of serum alkaline phosphatase （AKP） and its clinical implications in pregnant women, with especial emphases on fetal abnormalities. Methods Serum concentrations of AKP in 300 women of normal pregnancy and 117 pregnant women with fetal abnormalities were analyzed. Results In pregnant women with normal fetuses, AKP levels increased with gestational age, reached peak at the last trimester, and decreased remarkably after delivery. AKP levels in pregnant women with fetal cardiac defects were significantly lower than those in pregnant women with normal fetuses before 13 gestational weeks and during 21-24 gestational weeks. In addition, women with other fetal abnormalities had lower serum AKP levels during 17-21 gestational weeks when compared with women having normal pregnancies. Conclusion Serum AKP levels may be a marker of fetal abnormalities, but further studies are warranted.