小剂量奎尼丁对安替比林消除的影响

EFFECTS OF SMALL DOSE OF QUINIDINE ON THE ELIMINATION OF ANTIPYRINE IN MAN

用高效液相法测定了小剂量(5mg)奎尼丁对6名健康受试者唾液中安替比林的药动学参数、尿中安替比林及其代谢物3-羟甲基安替比林、4-羟基安替比林和去甲基安替比林排泄率的影响。结果表明,小剂量奎尼丁对唾液中安替比林的半衰期、消除速率常数、清除率、药一时曲线下面积和表观分布容积等药动学参数均无影响,对尿中安替比林、3-羟甲基安替比林、去甲基安替比林及总代谢物排泄量亦无明显影响,但能减少尿中4-羟基安替比林的排泄量(P<0.05)

The effects of single dose (5mg) of quinidine on the pharmacokinetics of antipyri-ne in saliva and the excretion ratios of antipyrine and its three main metabolites in urine were studied on 6 healthy volunteers with HPLC.Quinidine did not affect the antipyrine saliva pharmacokinetrics parameters, half life(t-1/2) .elimination constant(Kel), clearance rate(Cl), apparent distribution volume(Vd)and the area under the C-T curve (AUC).had no effects on the urine excreted total amount of antipyrine metabolites and the ratios of antipyrine,3-hydroXymethylantipyrine and norantipyrinc either,but could significantly reduce the urine excretion ratio of 4-hydroXyantipyrine(P<0.05)